Transcriptional and biochemical markers in transplanted Perca flavescens to characterize cadmium- and copper-induced oxidative stress in the field

Aquatic Toxicology
Michel A DefoPatrice Couture

Abstract

Despite recent progress achieved in elucidating the mechanisms underlying local adaptation to pollution, little is known about the evolutionary change that may be occurring at the molecular level. The goal of this study was to examine patterns of gene transcription and biochemical responses induced by metal accumulation in clean yellow perch (Perca flavescens) and metal depuration in contaminated fish in a mining and smelting region of Canada. Fish were collected from a reference lake (lake Opasatica) and a Cd, Cu and Zn contaminated lake (lake Dufault) located in the Rouyn-Noranda region (Qc, Canada) and caged for one or four weeks in their own lake or transplanted in the other lake. Free-ranging fish from the same lakes were also collected. Kidney Cd and Cu concentrations in clean fish caged in the contaminated lake increased with the time of exposure, but metal depuration did not occur in contaminated fish caged in the clean lake. After 4 weeks, the major retinoid metabolites analysed, the percentage of free dehydroretinol (dROH) and the retinol dehydrogenase-2 (rdh-2) transcription level in liver decreased in clean fish transplanted into the metal-contaminated lake, suggesting that metal exposure negatively impacted retinoi...Continue Reading

References

Apr 1, 1992·Archives of Environmental Contamination and Toxicology·A HontelaG Chevalier
May 6, 2003·Journal of Environmental Monitoring : JEM·Patrice Couture, James W Rajotte
Nov 17, 2004·Free Radical Biology & Medicine·Stephen S LeonardXianglin Shi
May 6, 2005·Environmental Science & Technology·Samuel N Luoma, Philip S Rainbow
Jul 12, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J G Scandalios
Mar 15, 2006·Nature Reviews. Genetics·Eric J Richards
Sep 12, 2006·Molecular Biology and Evolution·N Derome, L Bernatchez
Feb 20, 2007·Molecular BioSystems·Nancy D DenslowDavid S Barber
Oct 10, 2007·Molecular Ecology·Peter F LarsenVolker Loeschcke
Aug 5, 2008·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Charles GauthierPatrice Couture
Oct 18, 2008·Chemico-biological Interactions·Seung-Ah LeeNatalia Y Kedishvili
Sep 18, 2009·Ecotoxicology and Environmental Safety·Charles GauthierPatrice Couture
Dec 22, 2009·Molecular BioSystems·Raquel de Sousa AbreuChristine Vogel
Nov 16, 2010·Aquatic Toxicology·Volodymyr I Lushchak
Jun 30, 2011·Environmental Toxicology and Chemistry·Charles GauthierPatrice Couture
Dec 7, 2011·Aquatic Toxicology·Mikko Nikinmaa, Kalle T Rytkönen
Sep 11, 2012·Ecotoxicology and Environmental Safety·Michel A DefoPatrice Couture
Aug 21, 2013·Environmental Toxicology and Pharmacology·Qing ChenLi-juan Zhao
Dec 18, 2013·Environmental Science & Technology·Fabien PierronPatrice Gonzalez
Jan 24, 2014·Evolutionary Applications·Juha Merilä, Andrew P Hendry

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