Transcriptional and posttranscriptional regulation of HIV-1 gene expression.

Cold Spring Harbor Perspectives in Medicine
Jonathan Karn, C Martin Stoltzfus

Abstract

Control of HIV-1 gene expression depends on two viral regulatory proteins, Tat and Rev. Tat stimulates transcription elongation by directing the cellular transcriptional elongation factor P-TEFb to nascent RNA polymerases. Rev is required for the transport from the nucleus to the cytoplasm of the unspliced and incompletely spliced mRNAs that encode the structural proteins of the virus. Molecular studies of both proteins have revealed how they interact with the cellular machinery to control transcription from the viral LTR and regulate the levels of spliced and unspliced mRNAs. The regulatory feedback mechanisms driven by HIV-1 Tat and Rev ensure that HIV-1 transcription proceeds through distinct phases. In cells that are not fully activated, limiting levels of Tat and Rev act as potent blocks to premature virus production.

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Citations

Apr 2, 2013·Lancet·Christine KatlamaRafick P Sekaly
Apr 5, 2012·Cold Spring Harbor Perspectives in Medicine·Eric J Arts, Daria J Hazuda
Apr 17, 2013·Retrovirology·Alexander O PasternakBen Berkhout
Jan 24, 2014·PLoS Genetics·John M PaganoJohn T Lis
Aug 8, 2013·PloS One·Gwenola ManicStéphanie Bury-Moné
Jan 11, 2014·Future Virology·Sona Budhiraja, Andrew P Rice
Sep 26, 2013·International Journal of Molecular Sciences·Jacques Jean-PhilippeMassimo Caputi
Oct 6, 2015·Genes·Luis M AgostoAndrew J Henderson
May 27, 2014·Journal of Molecular Biology·Roni NowarskiMoshe Kotler
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Jun 18, 2014·Microbiology and Immunology·Akihito Machinaga, Sayaka Takase-Yoden
Jul 6, 2014·Journal of Theoretical Biology·Luis U Aguilera, Jesús Rodríguez-González
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