Understanding the organizational logic of neural circuits requires deciphering the biological basis of neuronal diversity and identity, but there is no consensus on how neuron types should be defined. We analyzed single-cell transcriptomes of a set of anatomically and physiologically characterized cortical GABAergic neurons and conducted a computational genomic screen for transcriptional profiles that distinguish them from one another. We discovered that cardinal GABAergic neuron types are delineated by a transcriptional architecture that encodes their synaptic communication patterns. This architecture comprises 6 categories of ∼40 gene families, including cell-adhesion molecules, transmitter-modulator receptors, ion channels, signaling proteins, neuropeptides and vesicular release components, and transcription factors. Combinatorial expression of select members across families shapes a multi-layered molecular scaffold along the cell membrane that may customize synaptic connectivity patterns and input-output signaling properties. This molecular genetic framework of neuronal identity integrates cell phenotypes along multiple axes and provides a foundation for discovering and classifying neuron types.
Morphological and Functional Characterization of Non-fast-Spiking GABAergic Interneurons in Layer 4 Microcircuitry of Rat Barrel Cortex
Leucine-rich repeat-containing synaptic adhesion molecules as organizers of synaptic specificity and diversity.
Expression of Transcripts Selective for GABA Neuron Subpopulations across the Cortical Visuospatial Working Memory Network in the Healthy State and Schizophrenia
Characterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor
Mapping the transcriptional diversity of genetically and anatomically defined cell populations in the mouse brain
Molecular expression profiles of morphologically defined hippocampal neuron types: Empirical evidence and relational inferences.
Transcriptional profiling aligned with in situ expression image analysis reveals mosaically expressed molecular markers for GABA neuron sub-groups in the ventral tegmental area.
Disruption of Transient SERT Expression in Thalamic Glutamatergic Neurons Alters Trajectory of Postnatal Interneuron Development in the Mouse Cortex.
Complex IV subunit isoform COX6A2 protects fast-spiking interneurons from oxidative stress and supports their function.
The ins and outs of inhibitory synaptic plasticity: Neuron types, molecular mechanisms and functional roles
Single-cell RNAseq characterization of anatomically-identified OLM interneurons in different transgenic mouse lines
Synaptic Zinc Enhances Inhibition Mediated by Somatostatin, but not Parvalbumin, Cells in Mouse Auditory Cortex.
Synaptic Mechanisms Underlying the Network State-Dependent Recruitment of VIP-Expressing Interneurons in the CA1 Hippocampus.
Quantitative cellular-resolution map of the oxytocin receptor in postnatally developing mouse brains.
Single-cell RNA-seq analysis revealed long-lasting adverse effects of tamoxifen on neurogenesis in prenatal and adult brains.
Intrinsic electrophysiological properties predict variability in morphology and connectivity among striatal Parvalbumin-expressing Pthlh-cells
Transcriptomic metaanalyses of autistic brains reveals shared gene expression and biological pathway abnormalities with cancer
Transcriptomic profile of the subiculum-projecting VIP GABAergic neurons in the mouse CA1 hippocampus
Tsc1 represses parvalbumin expression and fast-spiking properties in somatostatin lineage cortical interneurons
A regulatory variant of CHRM3 is associated with cannabis-induced hallucinations in European Americans
Regional transcriptome analysis of AMPA and GABAA receptor subunit expression generates E/I signatures of the human brain
Synaptic organisation and behaviour-dependent activity of mGluR8a-innervated GABAergic trilaminar cells projecting from the hippocampus to the subiculum
Inhibitory regulation of calcium transients in prefrontal dendritic spines is compromised by a nonsense Shank3 mutation.
Vasoactive intestinal peptide-expressing interneurons are impaired in a mouse model of Dravet syndrome
Nf1 deletion results in depletion of the Lhx6 transcription factor and a specific loss of parvalbumin+ cortical interneurons
Molecular profiling of single neurons of known identity in two ganglia from the crab Cancer borealis
Progressive divisions of multipotent neural progenitors generate late-born chandelier cells in the neocortex
AMPA receptor deletion in developing MGE-derived hippocampal interneurons causes a redistribution of excitatory synapses and attenuates postnatal network oscillatory activity.
Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer
Agonist-induced functional analysis and cell sorting associated with single-cell transcriptomics characterizes cell subtypes in normal and pathological brain.
Emergence of non-canonical parvalbumin-containing interneurons in hippocampus of a murine model of type I lissencephaly.
Diversification of molecularly defined myenteric neuron classes revealed by single-cell RNA sequencing.
Sustained Activation of PV+ Interneurons in Core Auditory Cortex Enables Robust Divisive Gain Control for Complex and Naturalistic Stimuli.
Hyperactive MEK1 Signaling in Cortical GABAergic Neurons Promotes Embryonic Parvalbumin Neuron Loss and Defects in Behavioral Inhibition.
Transcriptional and morphological profiling of parvalbumin interneuron subpopulations in the mouse hippocampus
Dysregulation of PGC-1α-Dependent Transcriptional Programs in Neurological and Developmental Disorders: Therapeutic Challenges and Opportunities.
Differential Synaptic Dynamics and Circuit Connectivity of Hippocampal and Thalamic Inputs to the Prefrontal Cortex.
A Picture Worth a Thousand Molecules-Integrative Technologies for Mapping Subcellular Molecular Organization and Plasticity in Developing Circuits.
Cell-type-specific recruitment of GABAergic interneurons in the primary somatosensory cortex by long-range inputs.
Single cell transcriptomics of primate sensory neurons identifies cell types associated with chronic pain.
Cajal-Retzius cells and GABAergic interneurons of the developing hippocampus: Close electrophysiological encounters of the third kind
Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function.
Synaptic inhibition in the neocortex: Orchestration and computation through canonical circuits and variations on the theme.
FXR1 regulation of parvalbumin interneurons in the prefrontal cortex is critical for schizophrenia-like behaviors.
Kcns3 deficiency disrupts Parvalbumin neuron physiology in mouse prefrontal cortex: Implications for the pathophysiology of schizophrenia.
Integrating barcoded neuroanatomy with spatial transcriptional profiling enables identification of gene correlates of projections.
Adhesion Molecules in Health and Disease
Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.
Cell Adhesion Molecules in the Brain
Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.
Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.
Basal Forebrain- Circuits
Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.