Transcriptional architecture of the primate neocortex

Neuron
Amy BernardEd S Lein

Abstract

Genome-wide transcriptional profiling was used to characterize the molecular underpinnings of neocortical organization in rhesus macaque, including cortical areal specialization and laminar cell-type diversity. Microarray analysis of individual cortical layers across sensorimotor and association cortices identified robust and specific molecular signatures for individual cortical layers and areas, prominently involving genes associated with specialized neuronal function. Overall, transcriptome-based relationships were related to spatial proximity, being strongest between neighboring cortical areas and between proximal layers. Primary visual cortex (V1) displayed the most distinctive gene expression compared to other cortical regions in rhesus and human, both in the specialized layer 4 as well as other layers. Laminar patterns were more similar between macaque and human compared to mouse, as was the unique V1 profile that was not observed in mouse. These data provide a unique resource detailing neocortical transcription patterns in a nonhuman primate with great similarity in gene expression to human.

References

Apr 11, 1975·Science·M C King, A C Wilson
Oct 8, 1998·The Journal of Cell Biology·G A ElderR A Lazzarini
Dec 26, 2001·Nucleic Acids Research·Ron EdgarAlex E Lash
May 24, 2003·Cerebral Cortex·Luca Muzio, Antonello Mallamaci
Oct 24, 2003·The Journal of Biological Chemistry·Elisabeth RaschpergerJonas Fuxe
Apr 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ed S LeinFred H Gage
Aug 4, 2004·Genome Research·Philipp KhaitovichSvante Pääbo
Aug 21, 2004·Neuroinformatics·Olaf Sporns, Jonathan D Zwi
Dec 22, 2004·Journal of Anatomy·Karl ZillesAxel Schleicher
Jul 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Matthew A ZapalaCarrolee Barlow
Nov 9, 2005·PLoS Biology·Matthew V RockmanGregory A Wray
Dec 22, 2005·Nature Neuroscience·Ken SuginoSacha B Nelson
Mar 21, 2006·Neuroscience Research·Tetsuo Yamamori, Kathleen S Rockland
May 2, 2006·Statistical Applications in Genetics and Molecular Biology·Bin Zhang, Steve Horvath
Oct 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Daniel B CampbellPat Levitt
Nov 3, 2006·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Danielle Smith Bassett, Ed Bullmore
Apr 14, 2007·Science·Rhesus Macaque Genome Sequencing and Analysis ConsortiumAnn S Zwieg
May 22, 2007·Nature Reviews. Neuroscience·Bradley J MolyneauxJeffrey D Macklis
Nov 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·B S AbrahamsDaniel H Geschwind
Nov 21, 2007·Bioinformatics·Peter LangfelderSteve Horvath
Jan 23, 2008·Nature Reviews. Neuroscience·Irina BystronP Rakic
Jun 6, 2008·Current Opinion in Neurobiology·Dennis Dm O'Leary, Setsuko Sahara
Oct 14, 2008·Nature Neuroscience·Michael C OldhamDaniel H Geschwind
Nov 15, 2008·Cerebral Cortex·Anna Hoerder-SuabedissenZoltán Molnár
Dec 17, 2008·Cerebral Cortex·Toru TakahataTetsuo Yamamori
Feb 5, 2009·Nature Reviews. Neuroscience·Ed Bullmore, Olaf Sporns
Feb 17, 2009·Nature Neuroscience·Lydia NgMichael J Hawrylycz
Apr 3, 2009·Annals of the New York Academy of Sciences·Leah Krubitzer
Jul 30, 2009·Molecular Systems Biology·Kellen WindenDaniel H Geschwind
Jan 5, 2010·Nature Reviews. Neuroscience·Karl Zilles, Katrin Amunts
Jan 22, 2010·Molecular Biology of the Cell·Celia QuevedoXosé R Bustelo
Aug 13, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zohar MukamelDaniel H Geschwind
Aug 27, 2011·Neuron·T Grant BelgardChris P Ponting

Citations

Jul 27, 2012·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Alex M Henry, John G Hohmann
Mar 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Nikola T MarkovHenry Kennedy
Jul 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·T Grant BelgardZoltán Molnár
Mar 27, 2013·Cerebral Cortex·Giorgio M InnocentiRoberto Caminiti
Jan 4, 2013·PLoS Computational Biology·Lior KirschGal Chechik
Apr 4, 2014·Nature·Jeremy A MillerEd S Lein
Apr 2, 2013·Cellular and Molecular Life Sciences : CMLS·R C Agis-Balboa, A Fischer
Nov 2, 2013·Science·Nikola T MarkovHenry Kennedy
Feb 13, 2016·Current Opinion in Neurobiology·Kenneth D Miller
Mar 18, 2015·The Journal of Comparative Neurology·Amy L BauernfeindChet C Sherwood
Jan 8, 2016·Proceedings of the National Academy of Sciences of the United States of America·Fenna M KrienenChet C Sherwood
Sep 18, 2013·Biological Psychiatry·Branka Hrvoj-MihicAlysson R Muotri
Jun 10, 2015·Proceedings of the National Academy of Sciences of the United States of America·Shyam SrinivasanCharles F Stevens
Nov 9, 2015·Current Opinion in Genetics & Development·Stephan J Sanders
Dec 8, 2015·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Debra L Silver
Jul 3, 2013·The Journal of Comparative Neurology·Juan F Montiel, Zoltán Molnár
Aug 29, 2013·The Journal of Comparative Neurology·Nikola T MarkovHenry Kennedy
Nov 17, 2015·Nature Neuroscience·Michael J HawrylyczEd S Lein
Jul 15, 2015·Genome Biology and Evolution·Amy L BauernfeindCourtney C Babbitt
Aug 15, 2015·BMC Genomics·Troy A HackettKaroly Mirnics
May 13, 2015·Brain Structure & Function·Andrzej NagalskiMarta B Wisniewska
Mar 19, 2014·Current Opinion in Neurobiology·Víctor Borrell, Magdalena Götz
Jul 11, 2015·Annual Review of Neuroscience·Jennifer Dugas-Ford, Clifton W Ragsdale
May 9, 2015·Human Molecular Genetics·Trygve BakkenEd S Lein
Jul 31, 2012·Neuron·Nicholas J Priebe, David Ferster
Aug 28, 2012·Neuron·Genevieve KonopkaDaniel H Geschwind
May 15, 2013·Transcription·Guang-Zhong Wang, Genevieve Konopka
Dec 20, 2014·Methods : a Companion to Methods in Enzymology·Emma M MyersJason W Bohland
Mar 27, 2012·Neuron·Zoltán Molnár, T Grant Belgard
Feb 25, 2015·Developmental Cell·Byoung-Il BaeChristopher A Walsh

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