Transcriptional changes induced by bovine papillomavirus type 1 in equine fibroblasts.

Journal of Virology
Z Q YuanLubna Nasir

Abstract

Bovine papillomavirus type 1 (BPV-1) and, less commonly, BPV-2 are associated with the pathogenesis of common equine skin tumors termed sarcoids. In an attempt to understand the mechanisms by which BPV-1 induces sarcoids, we used gene expression profiling as a screening tool to identify candidate genes implicated in disease pathogenesis. Gene expression profiles of equine fibroblasts transformed by BPV-1 experimentally or from explanted tumors were compared with those of control equine fibroblasts to identify genes associated with expression of BPV-1. Analysis of the microarray data identified 81 probe sets that were significantly (P < 0.01) differentially expressed between the BPV-1-transformed and control cell lines. Expression of several deregulated genes, including MMP-1, CXCL5, FRA-1, NKG7, TLR4, and the gene encoding the major histocompatibility complex class I (MHC-I) protein, was confirmed using other BPV-1-transformed cell lines. Furthermore, expression of these genes was examined using a panel of 10 sarcoids. Increased expression of MMP-1, CXCL5, FRA-1, and NKG7 was detected in a subset of tumors, and TLR4 and MHC I showed robust down-regulation in all tumors. Deregulated expression was confirmed at the protein level ...Continue Reading

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Citations

Jun 11, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joanne B WeidhaasDavid Gaffney
Mar 20, 2012·BMC Veterinary Research·Maria StrazzulloGiuseppe Borzacchiello
Dec 3, 2014·The Veterinary Journal·S MosseriA Kipar
Nov 22, 2008·The Veterinary Journal·Abigail L ClutterbuckAli Mobasheri
Apr 5, 2016·Veterinary and Comparative Oncology·N Terron-CanedoL Nasir
Aug 14, 2009·The Journal of General Virology·Barbara MarchettiM Saveria Campo
Jan 20, 2021·Veterinary Pathology·Magdalena OgłuszkaAndrzej Raś
Apr 16, 2011·The Veterinary Record·S StadlerS Brandt

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