Transcriptional control by chromosome-associated protein phosphatase-1

Biochemical Society Transactions
D Bennett

Abstract

Tight regulation of gene expression is critical for cells to respond normally to physiological and environmental cues and to allow cell specialization. Reversible phosphorylation of key structural and regulatory proteins, from histones to the transcriptional machinery, is acknowledged to be an important mechanism of regulating spatial and temporal patterns of gene expression. PP1 (protein phosphatase-1), a major class of serine/threonine protein phosphatase, is found at many sites on Drosophila polytene chromosomes where it is involved in controlling gene expression and chromatin structure. PP1 is targeted to different chromosomal loci through interaction with a variety of different regulatory subunits, which modify PP1's activity towards specific substrates. This mini-review gives an overview of known chromosome-associated PP1 complexes, their role in transcriptional control and the prospects for future analysis.

Citations

Feb 24, 2007·Nature Reviews. Molecular Cell Biology·Greg B G MoorheadAnnegret Ulke-Lemée
Jun 3, 2010·The Journal of Biological Chemistry·Jeong-Heon LeeDavid G Skalnik
Mar 14, 2009·The Journal of Biological Chemistry·Marcela PopescuSinisa Dovat
Jan 24, 2006·Chemistry & Biology·Hugo Ceulemans, Mathieu Bollen
Jul 2, 2010·Learning & Memory·Johannes GräffIsabelle M Mansuy

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