PMID: 8943074Nov 26, 1996Paper

Transcriptional control of circadian hormone synthesis via the CREM feedback loop

Proceedings of the National Academy of Sciences of the United States of America
N S FoulkesP Sassone-Corsi

Abstract

Transcription factor cAMP-responsive element modulator (CREM) plays a key physiological and developmental role within the hypothalamic-pituitary-gonadal axis. The use of an alternative, intronic promoter within the CREM gene is responsible for the production of a cAMP-inducible repressor, inducible cAMP early repressor (ICER). ICER negatively autoregulates the ICER promoter, thus generating a feedback loop. We have previously documented a striking, clock-driven circadian fluctuation of CREM expression in the pineal gland. Oscillating ICER levels tightly correlate with fluctuations in the synthesis of the pineal hormone melatonin, whose production is also driven by the endogenous clock. Melatonin in turn regulates the hypothalamic-pituitary axis. The enzyme serotonin N-acetyltransferase (NAT) catalyzes the rate limiting step in melatonin synthesis. Thus, oscillations in NAT levels determine the circadian synthesis of melatonin. Here we demonstrate that NAT expression is dramatically increased in CREM-deficient mice that we have generated by homologous recombination. Characterization of the NAT promoter shows the presence of a ICER binding site. In addition, transfection studies show that ICER powerfully represses NAT transcripti...Continue Reading

References

Jan 1, 1991·Development. Supplement·C Tickle
Jan 1, 1989·Journal of Pineal Research·M GotoS Ebihara
Feb 15, 1985·Science·L TamarkinO F Almeida
Jun 28, 1974·Science·J Axelrod
May 4, 1981·Life Sciences·D C KleinD A Auerbach
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M Menaker, S Wisner
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J S TakahashiM Menaker
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·L MonacoP Sassone-Corsi
Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·E Lalli, P Sassone-Corsi
Nov 10, 1995·The Journal of Biological Chemistry·R Baler, D C Klein
Feb 1, 1994·Current Biology : CB·J S Takahashi
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·A B DollinsM H Deng
Jan 1, 1995·Annual Review of Cell and Developmental Biology·P Sassone-Corsi

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Citations

May 13, 2009·Molecular Neurobiology·Gilyana Borlikova, Shogo Endo
Mar 9, 2005·Biochemical and Biophysical Research Communications·Akari InadaSusan Bonner-Weir
Mar 30, 2004·Brain Research. Molecular Brain Research·Lydia EngelRainer Spessert
Nov 5, 1997·Trends in Neurosciences·N S FoulkesP Sassone-Corsi
Nov 7, 1998·Biochimica Et Biophysica Acta·R Adroer, R Oliva
Apr 3, 2003·Brain Research. Molecular Brain Research·Elena DiazValérie Simonneaux
Dec 5, 1998·Brain Research. Molecular Brain Research·P H RoseboomD C Klein
Jun 10, 1998·Biology of the Cell·N S FoulkesP Sassone-Corsi
May 25, 1999·Progress in Neurobiology·J Falcón
Oct 6, 1999·Current Opinion in Genetics & Development·S A Brown, U Schibler
Nov 13, 1998·Current Opinion in Neurobiology·D WhitmoreN S Foulkes
Nov 13, 1998·Current Opinion in Neurobiology·X LiS H Snyder
May 23, 1998·The International Journal of Biochemistry & Cell Biology·P Sassone-Corsi
Jun 13, 2002·The European Journal of Neuroscience·Marie-Laure GaridouValérie Simonneaux
Nov 3, 1998·The EMBO Journal·A A MillerA Giangrande
Nov 18, 2008·Nucleic Acids Research·Kyung-Chul WooKyong-Tai Kim
Jun 6, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity·Nick A Ciccone, Ursula B Kaiser
Mar 28, 1998·The European Journal of Neuroscience·J R NaranjoP Sassone-Corsi
May 20, 1999·Annual Review of Pharmacology and Toxicology·J BorjiginS H Snyder
Jan 24, 2008·PloS One·Reeta RintamäkiJouko Lönnqvist
Aug 14, 2001·Biochemical and Biophysical Research Communications·F G LinW H Lee
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·R MaldonadoC Mazucchelli
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·X LiJ Borjigin
Jul 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Daiichiro NakaharaHitoshi Okamura
Jun 25, 2009·Journal of Neuroendocrinology·A SalingreV Simonneaux
Jun 17, 2008·Journal of Pineal Research·Marco KochHorst-Werner Korf

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