Transcriptional control of circadian metabolic rhythms in the liver

Diabetes, Obesity & Metabolism
S Li, Jiandie D Lin

Abstract

Diurnal metabolic rhythms add an important temporal dimension to metabolic homeostasis in mammals. Although it remains a challenge to untangle the intricate networks of crosstalk among the body clock, nutrient signalling and tissue metabolism, there is little doubt that the rhythmic nature of nutrient and energy metabolism is a central aspect of metabolic physiology. Disruption of the synchrony between clock and metabolism has been causally linked to diverse pathophysiological states. As such, restoring the rhythmicity of body physiology and therapeutic targeting directed at specific time windows during the day may have important implications in human health and medicine. In this review, we summarize recent findings on the integration of hepatic glucose metabolism and the body clock through a regulatory network centred on the PPARγ coactivator 1 (PGC-1) transcriptional coactivators. In addition, we discuss the transcriptional mechanisms underlying circadian control of the autophagy gene programme and autophagy in the liver.

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Citations

Aug 25, 2017·International Journal of Molecular Sciences·Ivonne Bazwinsky-WutschkeFaramarz Dehghani
Oct 27, 2017·Experimental Biology and Medicine·Kevin J CyrJohn P Wikswo
Mar 14, 2017·The Journal of Clinical Investigation·Geoffrey A PreidisDavid D Moore
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Mar 21, 2020·Frontiers in Oncology·Kholoud Arafa, Marwan Emara
Dec 18, 2020·Frontiers in Cell and Developmental Biology·Xiang WangZhicheng Gong
Mar 31, 2021·Chronobiology International·D Grillault LarocheC Marie-Claire
Apr 20, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Soumyaditya GhoshRoman V Kondratov
Aug 5, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yuval IshayYaron Ilan

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