PMID: 2498165Mar 1, 1989Paper

Transcriptional control of Drosophila fushi tarazu zebra stripe expression

Genes & Development
C R DearolfC S Parker

Abstract

The Drosophila segmentation gene fushi tarazu (ftz) is expressed in a characteristic pattern of seven stripes during early embryogenesis. We have used ftz-lacZ fusion genes to determine the effects of deleting relatively small segments of the ftz promoter region necessary for this expression. We find that this regulatory region contains multiple activator and repressor elements. The deletion of one particular activator element results in a preferential loss of expression in the posterior stripes, whereas the deletion of other activator elements causes a general reduction in expression throughout the germ band. The removal of repressor elements results in a loss of repression in the odd-numbered parasegments. We also find that the ftz upstream enhancer element functions primarily in epidermal cells. Our results indicate that ftz transcription is activated in each parasegment through the 'zebra stripe' promoter region and is then inhibited selectively in the odd-numbered parasegments by repressors that bind directly to elements within this promoter region.

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Citations

Mar 1, 1990·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C R DearolfC S Parker
Jan 1, 1991·Developmental Genetics·N PerrimonA Brand
Dec 16, 1992·Biochimica Et Biophysica Acta·D Read, J L Manley
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M L MuhichC S Parker
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·Y OhkumaC Desplan
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·C V KirchhamerE H Davidson
Jan 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Benjamin P BermanMichael B Eisen
Aug 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Vincent C Calhoun, Michael Levine
Jul 3, 2002·Proceedings of the National Academy of Sciences of the United States of America·Vincent C CalhounMichael Levine
Nov 4, 2008·Biochimica Et Biophysica Acta·Miriam I RosenbergClaude Desplan
Jun 1, 1993·Current Opinion in Cell Biology·H Jäckle, F Sauer
Aug 1, 1993·Current Opinion in Genetics & Development·M Hoch, H Jäckle
Aug 11, 2006·Biochemical and Biophysical Research Communications·Andrew C JamiesonPamela M Carroll
Aug 22, 1995·Proceedings. Biological Sciences·D L JenkinsJ F Brookfield
Nov 1, 1995·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Wolfgang JostDieter Maier
Aug 1, 2018·Proceedings of the National Academy of Sciences of the United States of America·Bomyi LimMichael Levine
Apr 1, 1995·Mechanisms of Development·Y Yu, L Pick
Sep 1, 1990·Trends in Genetics : TIG·M J Pankratz, H Jäckle
Sep 1, 1993·Molecular and Cellular Biology·W HanL Pick
May 1, 1991·Genes & Development·S SmallM Levine
Nov 1, 1990·Genes & Development·K A KellermanI Duncan

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