Transcriptional Control of Somatic Cell Reprogramming

Trends in Cell Biology
Yan XuMiguel A Esteban

Abstract

Somatic cells and pluripotent cells display remarkable differences in most aspects of cell function. Accordingly, somatic cell reprogramming by exogenous factors requires comprehensive changes in gene transcription to induce a forced pluripotent state, which is encompassed by a simultaneous transformation of the epigenome. Nevertheless, how the reprogramming factors and other endogenous regulators coordinate to suppress the somatic cell gene program and activate the pluripotency gene network, and why the conversion is multi-phased and lengthy, remain enigmatic. We summarize the current knowledge of transcriptional regulation in somatic cell reprogramming, and highlight new perspectives that may help to reshape existing paradigms.

References

Sep 11, 2002·Trends in Cell Biology·Tom BurdonPierre Savatier
Mar 3, 2007·The Journal of Biological Chemistry·Shwu-Yuan Wu, Cheng-Ming Chiang
Nov 22, 2007·Science·Junying YuJames A Thomson
Mar 29, 2008·Cell Stem Cell·Marius WernigRudolf Jaenisch
Mar 29, 2008·Cell Stem Cell·Matthias StadtfeldKonrad Hochedlinger
Apr 29, 2009·Cell Stem Cell·Hongyan ZhouSheng Ding
Aug 22, 2009·Genes & Development·Ana BanitoJesús Gil
Dec 29, 2009·Cell Stem Cell·Miguel Angel EstebanDuanqing Pei
May 4, 2010·Cell·Peter B RahlRichard A Young
May 28, 2010·Stem Cells and Development·Virgínia Picanço-CastroDimas Tadeu Covas
Jun 17, 2010·Cell·Nishant SinghalHans R Schöler
Jul 3, 2010·The Journal of Biological Chemistry·Jiekai ChenDuanqing Pei
Sep 8, 2010·Cell Research·Oscar H Ocaña, M Angela Nieto
Oct 5, 2010·Cell Stem Cell·Fang LiChuan-Yuan Li
Dec 7, 2010·Nature Cell Biology·Dong Wook HanHans R Schöler
Jan 8, 2011·Cell Stem Cell·Richard P KocheAlexander Meissner
Apr 9, 2011·Cell Stem Cell·Kyle M Loh, Bing Lim
Apr 9, 2011·Cell Stem Cell·Frederick Anokye-DansoEdward E Morrisey
May 11, 2011·Cold Spring Harbor Perspectives in Biology·J B Gurdon, Ian Wilmut
May 31, 2011·Cell Stem Cell·Norikatsu MiyoshiMasaki Mori

❮ Previous
Next ❯

Citations

Jul 16, 2016·Seminars in Cell & Developmental Biology·William E SamsaGuang Zhou
Jun 25, 2017·Current Opinion in Genetics & Development·Jaber Firas, Jose M Polo
Feb 1, 2018·Transgenic Research·Kim SchildersRobbert J Rottier
Apr 10, 2019·Nature Chemical Biology·Ayyub EbrahimiTamer T Önder
Oct 10, 2020·Nature Communications·Yinghua HuangBaoming Qin
Mar 9, 2021·Frontiers in Cell and Developmental Biology·Li SunAndrew P Hutchins

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved