Transcriptional control of the HERV-H LTR element of the GSDML gene in human tissues and cancer cells

Archives of Virology
H-S SinH-S Kim

Abstract

Long terminal repeats (LTRs) of human endogenous retroviruses (HERVs) have been reported to serve as alternative promoters in functional genes. The GSDML (gasdermin-like protein) gene located on human chromosome 17q21 has been found to be an oncogenomic recombination hotspot. Here, we identified the LTR element of HERV-H with reverse orientation as an alternative promoter of the GSDML gene and analyzed its expression pattern in human tissues and cancer cells. A reporter gene assay of the promoter activity of the LTR on the GSDML gene in human cancer cell lines (HCT-116 and HeLa) and a kidney cell line (Cos7) of African green monkey indicated that the LTR promoter with reverse orientation had stronger promoter activity than forward one. The transcripts of this LTR-derived promoter were widely distributed in various human tissues and cancer cells, whereas the transcripts of the cellular promoter were found only in stomach tissues and some cancer cells (HCT116, MCF7, U937, C-33A, and PC3). These findings suggest that the LTR element on the GSDML gene was integrated into the hominoid lineage and acquired the role of transcriptional regulation of human tissues and cancer cells.

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Citations

Jun 2, 2011·Mobile DNA·Keith R Oliver, Wayne K Greene
Apr 23, 2010·Genes & Genetic Systems·Hiromitsu KomiyamaToshihiko Shiroishi
Jan 5, 2012·Genes & Genetic Systems·Yun-Ji KimHeui-Soo Kim
Mar 29, 2014·PloS One·Marta Hergueta-RedondoGema Moreno-Bueno
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Nov 21, 2013·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Luolan LiMartin Hirst
Jan 8, 2019·Reviews in Medical Virology·Mengwen ZhangShu Zheng
May 18, 2007·Genes & Genetic Systems·Dae-Soo KimHeui-Soo Kim
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Oct 15, 2013·Genomics & Informatics·Yun-Jeong KwonHeui-Soo Kim
Apr 16, 2020·Acta Biochimica Et Biophysica Sinica·Zengzhang ZhengXing Liu
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Feb 24, 2015·Genomics & Informatics·Jeong-An GimHeui-Soo Kim
Sep 20, 2021·Journal of Molecular Biology·Emilie Bourdonnay, Thomas Henry

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