Transcriptional control region rearrangements associated with the evolution of JC polyomavirus

Virology
Yoshiaki YogoYukio Homma

Abstract

JC polyomavirus (JCV) isolates worldwide are classified into three super-lineages (A, B and C), with A and B further split into several lineages and sub-lineages. The transcriptional control region (TCR) of the JCV genome generally has the archetypal configuration, but rearranged TCRs have occasionally been detected in isolates from immunocompetent individuals. To investigate the phylogenetic significance of these rearrangements, we analyzed 298 TCR sequences all derived from complete JCV genomes directly cloned from the urine of non-immunocompromised individuals. While sporadic rearrangements were found in many lineages and sub-lineages, common rearrangements were identified in all, or essentially all, isolates belonging to particular lineages or sub-lineages. Interestingly, several common rearrangements were also detected as sporadic rearrangements in other lineages or sub-lineages. This observation suggests that during the course of JCV evolution, JCV strains with sporadic rearrangements became predominant over archetypal TCRs in some JCV lineages or sub-lineages.

References

Jun 1, 1990·The Journal of Infectious Diseases·T KitamuraY Yogo
Apr 1, 1983·The Journal of Infectious Diseases·P M ChestersD J McCance
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·T IidaY Yogo
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·C SugimotoY Yogo
Feb 13, 2001·Microbes and Infection·G L StonerC F Ryschkewitsch
Apr 12, 2001·The Journal of General Virology·H T AgostiniG L Stoner
Feb 16, 2002·Journal of Molecular Evolution·Chie SugimotoYoshiaki Yogo
Sep 5, 2002·Journal of Virology·Makoto SuzukiYoshiaki Yogo
Apr 17, 2003·Journal of Molecular Evolution·Angelo Pavesi
Dec 26, 2003·Journal of Medical Virology·Byung-Hoon JeongYong-Sun Kim
May 5, 2004·Reviews in Medical Virology·Yoshiaki YogoTadaichi Kitamura
Oct 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sohini RamachandranL Luca Cavalli-Sforza
Feb 22, 2008·Nature·Mattias JakobssonAndrew B Singleton

❮ Previous
Next ❯

Citations

Oct 25, 2012·Annual Review of Pathology·Sarah GheuensIgor J Koralnik
Jan 14, 2011·The Journal of Infectious Diseases·Martyn K White, Kamel Khalili
Mar 1, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Baljit K SaundhAntony Hale
Aug 1, 2014·Journal of Neurovirology·Melissa S MaginnisWalter J Atwood
May 8, 2013·Reviews in Medical Virology·Ugo MoensBernhard Ehlers
Aug 24, 2013·PloS One·Tom Van LoyLieven J Stuyver
Feb 7, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Frédéric BacchettaRenaud Du Pasquier
May 12, 2017·Biological Chemistry·Benedetta Assetta, Walter J Atwood
Jun 27, 2018·PloS One·Anne-Sophie L'HonneurStéphanie Bury-Moné

❮ Previous
Next ❯

Related Concepts

Related Feeds

BK Virus Infection

BK virus infection is a significant complication of modern immunosuppression used in kidney transplantation. Discover the latest research on BK virus infection here.