Transcriptional dysregulation in neurodegenerative diseases: Who tipped the balance of Yin Yang 1 in the brain?

Neural Regeneration Research
Zhefan Stephen Chen, Ho Yin Edwin Chan

Abstract

Yin Yang 1 (YY1) is a multi-functional transcription factor that regulates gene expression in a range of cell types, including neurons. It controls neuronal differentiation, as well as neuronal specification and migration during the development of the mammalian nervous system. Besides, YY1 also mediates the transcription of genes that are required for neuronal survival. An impairment of the transcriptional function of YY1 causes neuronal death. This review summarizes recent research findings that unveil the dysfunction of YY1 in multiple neurodegenerative disorders. The expression of disease proteins perturbs the function of YY1 via distinct molecular mechanisms, including recruitment to protein aggregates, protein degradation and aberrant nuclear/cytoplasmic shuttling. Understanding the pathogenic roles of YY1 will further broaden our knowledge of the disease mechanisms in distinct neurodegenerative disorders.

References

Aug 25, 2004·The Journal of Biological Chemistry·Matthew J MorganJean Paul Thiery
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May 20, 2008·Journal of Neurochemistry·Ye He, Patrizia Casaccia-Bonnefil
Mar 4, 2018·Acta Neuropathologica Communications·Sara E NasrabadyAdam M Brickman
Jul 22, 2018·EMBO Reports·Zhefan Stephen ChenHo Yin Edwin Chan
Jul 26, 2018·Annual Review of Cell and Developmental Biology·Albert A DavisDavid M Holtzman
Aug 9, 2018·Annual Review of Pathology·Andrew P LiebermanRoger L Albin

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Citations

Nov 2, 2019·International Journal of Molecular Sciences·Virginie Bottero, Judith A Potashkin
May 1, 2021·International Journal of Molecular Sciences·Virginie BotteroJudith A Potashkin

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