Transcriptional E2F1/2/5/8 as potential targets and transcriptional E2F3/6/7 as new biomarkers for the prognosis of human lung carcinoma

Aging
Cheng-Cao SunDe-Jia Li

Abstract

E2F is a group of genes that encode a family of transcription factors (TFs) in higher eukaryotes and participate in cell cycle regulation and DNA synthesis in mammalian cells. Evidence from cell lines, mouse models, and human tissues indicates that TFs are implicated in lung cancer (LC) tumorigenesis. However, the diverse expression patterns and prognostic values of eight E2Fs have yet to be elucidated. In the current study, we examined the transcriptional and survival data of E2Fs in patients with LC from ONCOMINE, GEPIA, Kaplan-Meier Plotter, and cBioPortal databases. We found that the expression levels of E2F1/2/3/5/6/7/8 were higher in lung adenocarcinoma and squamous cell lung carcinoma tissues than in lung tissues, whereas the expression level of E2F4 was lower in the former than in the latter. The expression levels of E2F2/4/5/7/8 were correlated with advanced tumor stage. Survival analysis using the Kaplan-Meier Plotter database revealed that the high transcription levels of E2F1/2/4/5/7/8 were associated with low relapse-free survival (RFS) in all of the patients with LC. Conversely, high E2F3/6 levels predicted high RFS in these patients. This study implied that E2F3/6/7 are potential targets of precision therapy for ...Continue Reading

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Nov 30, 2018·Bioscience Reports·Theasha ManicumBi-Cheng Chen
Dec 24, 2019·Frontiers in Genetics·Beatriz Andrea Otálora-OtáloraAdriana Rojas
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Aug 3, 2021·Disease Markers·Yan Tang, Chunsheng Hu
Sep 4, 2021·Frontiers in Oncology·Dan XieTing Ye

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Methods Mentioned

BETA
light microscopy

Software Mentioned

RNA Seq V2 RSEM
GEPIA
cBioPortal online tool for
DAVID ( Database for Annotation , Visualization , and Integrat...
cBioPortal

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