Transcriptional effects of prenatal and neonatal exposure to PFOS in developing rat brain

Environmental Science & Technology
Faqi WangLi Liu

Abstract

Perfluorooctane sulfonate (PFOS), a persistent and bioaccumulative compound, is widely distributed in the environment. To explore the molecular mechanism of neonatal neurotoxic effects, we evaluated the transcriptional effects of prenatal and neonatal exposure to PFOS in developing rat brain by performing gene expression profiling in the cerebral cortex. Dams received 3.2 mg/kg PFOS in their feed from gestational day 1 (GD1) to weaning (PND 21). Pups then had free access to treated feed until PND 35. Six Illumina RatRef-12 Expression BeadChips were used to identify gene expression changes on postnatal days (PNDs) 1, 7, and 35. Significantly affected genes (P < 0.05) were involved in neuroactive ligand-receptor interaction, calcium signaling pathways, cell communication, long-term potentiation/depression, the cell cycle, and peroxisome proliferator-activated receptor (PPAR) signaling. To compare prenatal and lactational exposure contributions to transcriptional effects, a subset of altered genes obtained from the gene-profile study that represented neurobiological functions was analyzed using RT-PCR in a follow-up cross-foster study lasting from PND1 to 21. Prenatal and postnatal exposure to PFOS caused potential neurotoxicity a...Continue Reading

References

Oct 20, 1995·Chemico-biological Interactions·A K SohleniusJ W DePierre
Dec 14, 1999·Learning & Memory·J D Sweatt
Mar 10, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R Sircar
May 12, 2001·Environmental Science & Technology·R Renner
May 15, 2001·Environmental Science & Technology·K J HansenH O Johnson
Jun 26, 2003·Brain Research. Molecular Brain Research·Paul R LeeJames I Koenig
Sep 2, 2003·Environmental Health Perspectives·Maureen E AustinSheba M J MohanKumar
Sep 29, 2004·Neuron·Robert C Malenka, Mark F Bear
Mar 2, 2005·Biochemical and Biophysical Research Communications·Kouji HaradaAkio Koizumi
Oct 27, 2005·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·R C GrastyJ M Rogers
Dec 2, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Grewo LimJianren Mao
Jan 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·John D H SteadHuda Akil
May 5, 2006·Brain : a Journal of Neurology·S F Cooke, T V P Bliss
Jan 16, 2007·International Archives of Occupational and Environmental Health·O MidaschJ Angerer
May 22, 2007·Neurobiology of Aging·Jonathan Brouillette, Rémi Quirion
Jun 15, 2007·Toxicology·Leo W Y YeungPaul K S Lam
Apr 15, 2008·Toxicology and Applied Pharmacology·Xiongjie ShiBingsheng Zhou
Aug 12, 2008·Toxicology·James A BjorkKendall B Wallace
Feb 13, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Niclas JohanssonHenrik Viberg
Mar 7, 2009·Journal of Molecular and Cellular Cardiology·Andrew P Halestrap
Jan 1, 2005·Environmental Toxicology and Pharmacology·Wenyue HuJohn P Giesy
May 1, 2009·Environmental Toxicology and Pharmacology·Chun-Yang LiaoGui-Bin Jiang

❮ Previous
Next ❯

Citations

Feb 23, 2013·Current Opinion in Pediatrics·Manish Arora, Christine Austin
Jul 14, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Cristina G CassoneSean W Kennedy
Dec 22, 2015·Environmental Toxicology and Pharmacology·Stefan Hallgren, Henrik Viberg
Jan 25, 2011·The Mount Sinai Journal of Medicine, New York·Amir Miodovnik
Oct 13, 2010·Neurotoxicology·Huai-Cai ZengShun-Qing Xu
May 18, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Xiaohui LiuShuang Hao
Dec 20, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yu WangXie Quan
Mar 26, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Faqi WangJunsheng Ma
Dec 13, 2018·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Tanja Schwerdtle
Sep 1, 2020·Environmental Pollution·G López-BerenguerE Martínez-López
Feb 21, 2021·The Science of the Total Environment·Clare DeathTarah Hagen
Sep 3, 2021·Journal of Hazardous Materials·S T M L D SenevirathnaArumugam Sathasivan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.