Transcriptional Factor PU.1 Regulates Decidual C1q Expression in Early Pregnancy in Human

Frontiers in Immunology
Shanmuga Priyaa MadhukaranJinhua Lu

Abstract

C1q is the first recognition subcomponent of the complement classical pathway, which in addition to being synthesized in the liver, is also expressed by macrophages and dendritic cells (DCs). Trophoblast invasion during early placentation results in accumulation of debris that triggers the complement system. Hence, both early and late components of the classical pathway are widely distributed in the placenta and decidua. In addition, C1q has recently been shown to significantly contribute to feto-maternal tolerance, trophoblast migration, and spiral artery remodeling, although the exact mechanism remains unknown. Pregnancy in mice, genetically deficient in C1q, mirrors symptoms similar to that of human preeclampsia. Thus, regulated complement activation has been proposed as an essential requirement for normal successful pregnancy. Little is known about the molecular pathways that regulate C1q expression in pregnancy. PU.1, an Ets-family transcription factor, is required for the development of hematopoietic myeloid lineage immune cells, and its expression is tissue-specific. Recently, PU.1 has been shown to regulate C1q gene expression in DCs and macrophages. Here, we have examined if PU.1 transcription factor regulates decidual...Continue Reading

References

May 1, 1989·The American Journal of Anatomy·S R JohnsonP K Lala
Jan 21, 1988·Nature·F Moreau-GachelinP Tambourin
Mar 1, 1983·American Journal of Reproductive Immunology : AJRI·M Kearns, P K Lala
May 1, 1982·The Journal of Experimental Medicine·M Kearns, P K Lala
Jan 1, 1996·Molecular and Cellular Biology·M J Klemsz, R A Maki
Mar 23, 2005·Experimental Hematology·Jonathan BackPhilippe Kastner
Apr 28, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·Uma SinghAndrés López Bernal
May 4, 2005·The Journal of Experimental Medicine·Aleksandar DakicStephen L Nutt
Jan 30, 2007·Nature Reviews. Immunology·Frank Rosenbauer, Daniel G Tenen
Nov 27, 2008·The Journal of Clinical Investigation·Vicki PlaksSteffen Jung
Jun 4, 2010·Journal of Leukocyte Biology·Nardhy Gomez-LopezDavid M Olson
Sep 3, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chiara AgostinisFrancesco Tedesco
Aug 24, 2011·Hypertension·Jameel SinghGuillermina Girardi
Oct 6, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Shereen A Turkistany, Rodney P DeKoter
Jun 8, 2012·American Journal of Reproductive Immunology : AJRI·Tsvetelina OreshkovaMilena Mourdjeva

❮ Previous
Next ❯

Citations

Oct 1, 2016·Journal of Reproductive Immunology·Chiara AgostinisRoberta Bulla
Jan 8, 2019·American Journal of Reproductive Immunology : AJRI·Yan-Ran ShengXiao-Yong Zhu
Jul 10, 2019·Archivum Immunologiae Et Therapiae Experimentalis·Manoj K JenaNihar R Nayak
Jun 10, 2017·Frontiers in Immunology·Jinhua Lu, Uday Kishore

❮ Previous
Next ❯

Methods Mentioned

BETA
FCS
PCR
confocal microscopy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.