Transcriptional meta-analysis of regulatory B cells.

European Journal of Immunology
Florian DuboisRichard Danger

Abstract

Regulatory B cells (Bregs) have the ability to regulate inflammation in various pathological situations, making them key players in immune regulation. Several mechanisms have been described and we recently identified a GZMB expressing Breg population in kidney transplanted patients who tolerate a kidney graft. To further investigate their biology and mechanisms, we conducted a transcriptomic analysis by RNAseq of these cells and we performed the first weighted meta-analysis of publicly available transcriptomic data from published Breg studies both in humans and mice. We identified two distinct and unique transcriptional signatures of 126 and 93 genes, respectively, associated with these Bregs. While we highlighted genes coding for proteins with potent involvement in regulatory functions, proliferation, and coding for transcription factors, the comparison between humans and mice did not allow identifying a common pattern. Thus, our results suggest distinct species-restricted Breg transcriptional signatures in humans and mice.

References

Sep 24, 2002·Nature Immunology·Simon FillatreauStephen M Anderton
Feb 20, 2003·The Journal of Experimental Medicine·Claudia MauriMarco Londei
Oct 6, 2005·Human Molecular Genetics·Guiqing HuangColin Collins
Apr 25, 2006·Biostatistics·W Evan JohnsonAriel Rabinovic
Oct 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lixin RuiChristopher C Goodnow
Apr 16, 2008·Molecular and Cellular Biology·Ayumu NakashimaYukio Kato
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bitao LiangRaphael Clynes
Aug 5, 2009·Proceedings of the National Academy of Sciences of the United States of America·Dat Q TranEthan M Shevach
Jan 20, 2010·Nature Immunology·Shane CrottyStephen P Schoenberger
Feb 12, 2010·Nature·Stuart B SmithMichael S German
Apr 16, 2010·European Journal of Immunology·Magdalena HagnBernd Jahrsdörfer
Jul 10, 2010·Bioinformatics·Cristen J WillerGonçalo R Abecasis
Aug 12, 2010·Journal of Leukocyte Biology·Julie Denoeud, Muriel Moser
Dec 1, 2010·Nucleic Acids Research·Donna MaglottTatiana Tatusova
May 4, 2011·Cold Spring Harbor Protocols·Benedikt ZacherAchim Tresch
Dec 27, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Damian MasedaThomas F Tedder
Mar 30, 2012·Omics : a Journal of Integrative Biology·Guangchuang YuQing-Yu He
Nov 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Hongsheng WangHerbert C Morse
Feb 7, 2013·Cancer Research·Stefanie LindnerBernd Jahrsdörfer
Mar 5, 2013·The Journal of Allergy and Clinical Immunology·Willem van de VeenMübeccel Akdis
Sep 24, 2013·Nature Methods·Simone PicelliRickard Sandberg
Dec 21, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M ChesneauS Brouard
Jan 5, 2014·Nature Protocols·Simone PicelliRickard Sandberg
Feb 4, 2014·Genome Biology·Charity W LawGordon K Smyth
Mar 7, 2014·PloS One·Siniša HrvatinDouglas A Melton
Jul 6, 2014·Current Protocols in Molecular Biology·John J TrombettaAviv Regev
Aug 1, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wenyu LinSébastien Calbo
Oct 8, 2014·The Journal of Experimental Medicine·Bettina GrötschJean-Pierre David
Jan 22, 2015·Nucleic Acids Research·Matthew E RitchieGordon K Smyth
Mar 13, 2015·European Journal of Immunology·Adnan R KhanPadraic G Fallon
Mar 18, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christof KaltenmeierBernd Jahrsdörfer
Apr 23, 2015·Immunity·Elizabeth C Rosser, Claudia Mauri
May 23, 2015·International Immunology·Avijit RayBonnie N Dittel
Jun 14, 2015·International Immunology·Claudia Mauri, Madhvi Menon

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Citations

Feb 10, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Margaux PacaudSophie Brouard
Aug 17, 2021·Frontiers in Immunology·Daniil ShevyrevVladimir Kozlov

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