PMID: 9553719Apr 29, 1998Paper

Transcriptional modulation of foreign gene expression in engineered somatic tissues

Cell Biology and Toxicology
D Bohl, J M Heard

Abstract

Many diseases that are candidates for gene therapy require that the therapeutic gene expression level be controlled to ensure biological efficacy and to prevent toxic effects. Various systems have been described that allow transcriptional regulation by artificial chimeric transactivators in mammalian cells. This paper describes these various systems and discusses their interests for gene therapy.

Citations

Mar 14, 2002·Biochemical and Biophysical Research Communications·Hiroshi TakamiTatsuo Muramatsu

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.