Transcriptional mutagenesis by 8-oxodG in α-synuclein aggregation and the pathogenesis of Parkinson's disease

Experimental & Molecular Medicine
Sambuddha BasuYoon-Seong Kim

Abstract

Parkinson's disease (PD) is an age-related progressive neurodegenerative disease associated with selective loss of dopaminergic neurons. The characteristic hallmark of the disease is intracytoplasmic proteinacious inclusion bodies called Lewy bodies, primarily consisting of a presynaptic protein α-synuclein. Oxidative stress-mediated damage to macromolecules have been shown to occur frequently in PD. Oxidative damage to DNA in the form of oxidized guanine (8-oxodG) accumulates in both the mitochondrial and nuclear DNA of dopaminergic neurons of the substantia nigra in PD. 8-oxodG-mediated transcriptional mutagenesis has been shown to have the potential to alter phenotype of cells through production of mutant pool of proteins. This review comprehensively summarizes the role of oxidative stress-mediated damage incurred during neurodegeneration, and highlights the scope of transcriptional mutagenesis event in leading to α-synuclein aggregation as seen in PD.

References

Nov 1, 1991·Journal of Neurochemistry·D Ben-ShacharM B Youdim
Feb 1, 1989·Journal of Neurochemistry·D T DexterC D Marsden
Feb 1, 1989·Journal of Neurochemistry·P RiedererM B Youdim
Dec 13, 1982·Neuroscience Letters·T L PerryS Hansen
Feb 1, 1997·Annals of Neurology·M E CudkowiczR H Brown
May 26, 1998·Journal of Neuropathology and Experimental Neurology·P F GoodC W Olanow
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·A KlunglandD E Barnes
Dec 2, 2000·Nature Neuroscience·R BetarbetJ T Greenamyre
Jan 29, 2002·Nature Cell Biology·Hideo FujiwaraTakeshi Iwatsubo
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jiankang LiuBruce N Ames
Jun 18, 2002·Trends in Molecular Medicine·Rejko KrügerJörg B Schulz
Jun 28, 2002·Free Radical Biology & Medicine·Sankar MitraTapas K Hazra
Aug 29, 2002·Nature Cell Biology·Ikuko FujiwaraShin'ichi Ishiwata
Sep 5, 2002·Annals of Neurology·John E DudaJohn Q Trojanowski
Dec 4, 2002·Nature Reviews. Neuroscience·Julie Lotharius, Patrik Brundin
Jan 2, 2003·DNA Repair·Thierry Nouspikel, Philip C Hanawalt
Jul 2, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marcus S CookeJoseph Lunec
Oct 29, 2003·Molecular Cell·Damien BrégeonPaul W Doetsch
Nov 1, 2003·Science·A B SingletonK Gwinn-Hardy
Feb 3, 2004·Annals of Neurology·Juan J ZarranzJusto G de Yebenes
Aug 10, 2004·Nature Medicine·Julie K Andersen
Sep 14, 2004·Nature Biotechnology·Ana-Maria Fernandez-EscamillaLuis Serrano
Sep 29, 2004·Lancet·Marie-Christine Chartier-HarlinAlain Destée
Apr 29, 2005·Journal of Neurochemistry·J WangM A Lovell

❮ Previous
Next ❯

Citations

Jan 10, 2018·Frontiers in Aging Neuroscience·Sandra ZárateRicardo Gredilla
Sep 2, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Shunsuke Koga, Dennis W Dickson
Sep 25, 2020·Chemical Society Reviews·Cécile MingardShana J Sturla
Mar 19, 2020·International Journal of Molecular Sciences·Ewelina WoźniakPaulina Gorzelak-Pabiś
Jan 11, 2020·Mechanisms of Ageing and Development·Mansi BabbarVilhelm A Bohr
Nov 28, 2021·International Journal of Molecular Sciences·Marianna MarinoAntonietta Santoro

❮ Previous
Next ❯

Software Mentioned

TANGO

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Alpha-Synuclein Aggregation

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

Related Papers

Biochemical Pharmacology
Srinivas BharathJulie K Andersen
The American Journal of Pathology
Micha M M WilhelmusJeroen J M Hoozemans
Molecular Neurobiology
Jing Zhang, David R Goodlett
© 2021 Meta ULC. All rights reserved