Transcriptional programming of dendritic cells for enhanced MHC class II antigen presentation

Nature Immunology
Bryan Vander LugtHarinder Singh

Abstract

CD11b(+) dendritic cells (DCs) seem to be specialized for presenting antigens via major histocompatibility (MHC) class II complexes to stimulate helper T cells, but the genetic and regulatory basis for this is not established. Conditional deletion of Irf4 resulted in loss of CD11b(+) DCs, impaired formation of peptide-MHC class II complexes and defective priming of helper T cells but not of cytotoxic T lymphocyte (CTL) responses. Gene expression and chromatin immunoprecipitation followed by deep sequencing (ChIP-Seq) analyses delineated an IRF4-dependent regulatory module that programs enhanced MHC class II antigen presentation. Expression of the transcription factor IRF4 but not of IRF8 restored the ability of IRF4-deficient DCs to efficiently process and present antigen to MHC class II-restricted T cells and promote helper T cell responses. We propose that the evolutionary divergence of IRF4 and IRF8 facilitated the specialization of DC subsets for distinct modes of antigen presentation and priming of helper T cell versus CTL responses.

References

Oct 27, 1991·Nature· Rudensky AYuC A Janeway
Jan 14, 1994·Cell·K A HogquistF R Carbone
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·M RescignoP Ricciardi-Castagnoli
Feb 19, 2000·Current Opinion in Immunology·R BuschE D Mellins
Apr 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Subhayu BasuRon Weiss
Jun 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Shoichi SuzukiAtsushi Kumatori
Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomohiko TamuraKeiko Ozato
Oct 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Malin LindstedtCarl A K Borrebaeck
May 2, 2006·Statistical Applications in Genetics and Molecular Biology·Gordon K Smyth
Jun 13, 2006·Nature Immunology·Ulf KleinRiccardo Dalla-Favera
Jan 6, 2007·Science·Diana DudziakMichel C Nussenzweig
Jun 27, 2007·The Journal of Experimental Medicine·Michele L CatonBoris Reizis
Aug 28, 2007·Bioinformatics·Matthew E RitchieGordon K Smyth
Sep 19, 2008·Nature Immunology·Tracy S P HengUNKNOWN Immunological Genome Project Consortium
Nov 17, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yueh-Hsuan ChanKuo-I Lin
Mar 31, 2010·The Journal of Experimental Medicine·Brian T EdelsonKenneth M Murphy
Jul 17, 2012·Nature Immunology·Jennifer C MillerUNKNOWN Immunological Genome Consortium
Aug 31, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sandra BajañaSusan Kovats
Nov 20, 2012·Nature Immunology·Ansuman T SatpathyKenneth M Murphy

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Citations

May 24, 2014·Nature Reviews. Immunology·Bernard MalissenSandrine Henri
Mar 17, 2016·Journal of Immunology Research·Alex Steimle, Julia-Stefanie Frick
Jan 13, 2016·The Journal of Experimental Medicine·Hongkang XiMenno van Lookeren Campagne
Nov 26, 2015·Frontiers in Immunology·Reinhard Obst
Jun 19, 2015·Nature Immunology·Deborah R Winter, Ido Amit
May 11, 2015·Seminars in Cell & Developmental Biology·Andreas SchlitzerFlorent Ginhoux
Oct 14, 2014·Frontiers in Immunology·Michael R YeamanJohn P Hennessey
Aug 15, 2014·Frontiers in Physiology·Dimitry A ChistiakovYuri V Bobryshev
Jun 7, 2014·Frontiers in Immunology·Kirsteen M TullettKristen J Radford
Jun 10, 2014·Frontiers in Immunology·Lillian Cohn, Lélia Delamarre
Nov 7, 2015·PloS One·Michela ManniAlessandra B Pernis
Jan 7, 2016·Annual Review of Immunology·Theresa L MurphyKenneth M Murphy
May 18, 2016·The Journal of Experimental Medicine·Samuele CalabroStephanie C Eisenbarth
May 28, 2016·Nature Reviews. Immunology·Yasmine Belkaid, Samira Tamoutounour
Nov 8, 2016·Cellular & Molecular Immunology·Juan Liu, Xuetao Cao
Jan 13, 2017·Cell Death & Disease·Yuechen LuoXiaoming Feng
Apr 25, 2015·Veterinary Pathology·R RogersJ D Webster
Oct 21, 2016·Scientific Reports·Justus MahnkeHans-Willi Mittrücker
Apr 17, 2017·Molecular and Cellular Endocrinology·Vassil Dimitrov, John H White
Apr 20, 2017·Science Signaling·Kate SengerAli A Zarrin
Apr 5, 2016·Immunology·Michael Bscheider, Eugene C Butcher
Jun 10, 2017·Nature Communications·Johannes U MayerSimon W Milling
Feb 22, 2017·Pflügers Archiv : European journal of physiology·Stoyan Ivanov, Gwendalyn J Randolph
Jan 18, 2017·Proceedings of the National Academy of Sciences of the United States of America·Kensuke MiyakeHajime Karasuyama
Feb 13, 2017·The Journal of Allergy and Clinical Immunology·Julie DeckersHamida Hammad
Jun 29, 2017·Immunological Reviews·Masato Kubo
Jul 29, 2017·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Radika SoysaI Nicholas Crispe
Nov 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erika TakacsIstvan Szatmari
Jan 15, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiangyun YinLiguo Zhang
Dec 15, 2017·Frontiers in Immunology·Kalum ClaytonMarta E Polak
Aug 2, 2018·Journal of Hematology & Oncology·Pu FangHong Wang
Oct 1, 2017·Cold Spring Harbor Perspectives in Biology·David A AndersonCarlos G Briseño
Nov 24, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Hedong ZhangWenhao Chen
Nov 23, 2018·Nature Reviews. Immunology·S C Eisenbarth
Mar 31, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shu-Chen HungElizabeth D Mellins
Mar 25, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brendan W MacNabbJustin Kline
Apr 17, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ming-Chin LeeAndrew D Cook
Jul 10, 2019·Proceedings of the National Academy of Sciences of the United States of America·Salix BouletNathalie Labrecque

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