Transcriptional regulation by coactivators in embryonic stem cells.

Trends in Cell Biology
Yick W FongRobert Tjian

Abstract

Embryonic stem (ES) cells, like all cell types, are defined by their unique transcriptional signatures. The ability of ES cells to self-renew or exit the pluripotent state and enter differentiation requires extensive changes in their transcriptome and epigenome. Remarkably, transcriptional programs governing each cell fate must remain sufficiently malleable so that expression of only a handful of transcriptional activators can override the pre-existing state by collaborating with an unexpectedly elaborate collection of coactivators to specify, restrict and stabilize the new state. Here, we discuss recent advances in our understanding of how the same coactivator can interpret multiple lines of information encoded by different activators and integrate signals from diverse regulators into stem cell-specific transcriptional outputs.

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Citations

Apr 23, 2015·Proceedings of the National Academy of Sciences of the United States of America·Claudia CattoglioRobert Tjian
Sep 1, 2014·Current Opinion in Genetics & Development·Xin Huang, Jianlong Wang
Nov 12, 2013·Molecular Cell·Yick W FongRobert Tjian
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Aug 28, 2013·Chemical Reviews·Robert O J Weinzierl
Jan 25, 2017·Proceedings of the National Academy of Sciences of the United States of America·Cheng Wang, Stephen P Goff
Oct 16, 2019·Journal of Cellular Physiology·Jianyi DingYing Jin
Aug 30, 2019·Nature·Patrick Cramer
Jun 18, 2021·World Journal of Stem Cells·Munender VodnalaYick W Fong

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