Transcriptional regulation by extracellular signals: mechanisms and specificity

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Transcriptional regulation by extracellular signals: mechanisms and specificity

Abstract

References

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter.

I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention.

Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB

Interferon-alpha activates binding of nuclear factors to a sequence element in the c-fos proto-oncogene 5'-flanking region

The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases

Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor

Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: regulation by the N-terminal delta domain

The regulation of transcription by phosphorylation.

CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases.

Characterization of motifs which are critical for activity of the cyclic AMP-responsive transcription factor CREB.

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

The origin of pattern and polarity in the Drosophila embryo

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

Drosophila Toll and IL-1 receptor

Distinct protein targets for signals acting at the c-fos serum response element

Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

Phosphorylation of c-jun mediated by MAP kinases

Signalling and superinduction.

Effect of protein synthesis inhibitors on growth factor activation of c-fos, c-myc, and actin gene transcription.

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

Occupation of the c-fos serum response element in vivo by a multi-protein complex is unaltered by growth factor induction.

Transcriptional autoregulation of the proto-oncogene fos

Yeast peptide pheromones, a-factor and alpha-factor, activate a common response mechanism in their target cells.

Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

Expression of a peptide inhibitor of protein phosphatase 1 increases phosphorylation and activity of CREB in NIH 3T3 fibroblasts.

Activation of Raf as a result of recruitment to the plasma membrane

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

MAP kinase pathways in yeast: for mating and more

MAPKs: new JNK expands the group

The cAMP-regulated transcription factor CREB interacts with a component of the TFIID complex

Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B

Nuclear protein CBP is a coactivator for the transcription factor CREB

Blockage of NF-kappa B signaling by selective ablation of an mRNA target by 2-5A antisense chimeras

A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27

Drosophila Jun mediates Ras-dependent photoreceptor determination

Regulation of the dorsal morphogen by the Toll and torso signaling pathways: a receptor tyrosine kinase selectively masks transcriptional repression

The global transcriptional regulators, SSN6 and TUP1, play distinct roles in the establishment of a repressive chromatin structure

EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor

PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation

The high mobility group protein HMG I(Y) is an essential structural component of a virus-inducible enhancer complex

Ras/MAP kinase-dependent and -independent signaling pathways target distinct ternary complex factors

Signal transduction by tumor necrosis factor mediated by JNK protein kinases.

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation

Dual modes of control of c-fos mRNA induction by intracellular calcium in T cells.

Inhibition of v-raf-dependent c-fos expression and transformation by a kinase-defective mutant of the mitogen-activated protein kinase Erk2.

Function and activation of NF-kappa B in the immune system

Citations

Immunolocalization of the mitogen-activated protein kinases p42MAPK and JNK1, and their regulatory kinases MEK1 and MEK4, in adult rat central nervous system

Control of proteinase expression by phorbol-ester- and Fos-dependent pathways in human non-small-cell lung-cancer cells

Integrin-dependent signal transduction

Antiproliferative effect of elevated glucose in human microvascular endothelial cells

Effects of hyperthermia on the cytoskeleton and focal adhesion proteins in a human thyroid carcinoma cell line

Nuclear accumulation of multiple protein kinases during prolactin-induced proliferation of Nb2 rat lymphoma cells

Identification of a potential physiological substrate for oncogenic Ras-activated protein kinases in activated Xenopus egg extracts: correlation with oncogenic Ras-induced cell cycle arrest

Repression of mitogen-activated protein kinases ERK1/ERK2 activity by a protein tyrosine phosphatase in rat fibroblasts transformed by upstream oncoproteins

MAP kinases, phosphatidylinositol 3-kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor

Role of diacylglycerol (DAG) in hormonal induction of S phase in hepatocytes: the DAG-dependent protein kinase C pathway is not activated by epidermal growth factor (EGF), but is involved in mediating the enhancement of responsiveness to EGF by vasopressin, angiotensin II, and norepinephrine

TrkA glycosylation regulates receptor localization and activity

bFGF and LIF signaling activates STAT3 in proliferating myoblasts

Nuclear factor-kappa B in rheumatoid synovium. Localization of p50 and p65

Activation of mammalian gene expression by the UV component of sunlight--from models to reality

Multiple growth factors are associated with lesions of atherosclerosis: specificity or redundancy?

DNA elements responsive to auxin

p21Ras downstream effectors are increased in activity or expression in mouse liver tumors but do not differ between ras-mutated and ras-wild-type lesions

Cell density dependent regulation of AP-1 activity is important for chondrogenic differentiation of C3H10T1/2 mesenchymal cells

SB203580 promotes EGF-stimulated early morphological differentiation in PC12 cell through activating ERK pathway

Methamphetamine induces AP-1 and NF-kappaB binding and transactivation in human brain endothelial cells

Oxidative stress, signal transduction, and intercellular communication in radiation carcinogenesis

Identification of immune-related protein kinases from mosquitoes (Aedes aegypti)

Regulation of stress-induced transcriptional changes in the hypothalamic neurosecretory neurons

Exploring the role of homeobox and zinc finger proteins in pancreatic cell proliferation, differentiation, and apoptosis

Immunomodulated signaling in macrophages: Studies on activation of Raf-1, MAPK, cPLA(2) and secretion of IL-12

Impact of IFNalpha2b upon pSTAT3 and the MEK/ERK MAPK pathway in melanoma