Transcriptional regulation of autophagy in RAS-driven cancers

The Journal of Clinical Investigation
Ravi K Amaravadi

Abstract

RAS-driven cancers exhibit variable dependency on autophagy for survival; however, it is not fully understood how. In this issue of the JCI, Cheong and colleagues demonstrate that RAS-dependent elevation of casein kinase 1α (CK1α) negatively regulates autophagy at the level of autophagy gene transcription. Moreover, combined inhibition of both CK1α and autophagy reduced proliferation of RAS-driven tumors. The results of this study provide insight into the connection between mutant RAS and autophagy, and suggest targeting CK1α as a potential therapeutic strategy to modulate autophagy in RAS-driven cancers.

References

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Mar 24, 2015·The Journal of Clinical Investigation·Jit Kong CheongDavid M Virshup

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Citations

Jan 13, 2018·Biology Letters·Wei Xie, Jun Zhou
Jun 8, 2021·Molecular Therapy Oncolytics·Zhixia ZhouPeifeng Li

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Methods Mentioned

BETA
xenografts
xenograft

Clinical Trials Mentioned

NCT01320085
NCT01363232
NCT01781572

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