Transcriptional regulation of cadherins during development and carcinogenesis

The International Journal of Developmental Biology
Héctor PeinadoAmparo Cano

Abstract

The cadherin superfamily of Ca(2+)-dependent homophilic adhesion molecules plays a critical role in regulating cell-to-cell interactions. During development, the expression of different cadherins is highly dynamic, since they are associated with the morphogenesis, establishment and/or maintenance of different tissues. Alterations in cadherin expression or function occur frequently during carcinogenesis, such as the loss of the epithelial cadherin (E-cadherin) and/or the aberrant expression of other cadherins. Indeed, the aberrant expression of cadherins has been detected during carcinoma invasion, a process which is reminiscent of the epithelial-mesenchymal transition (EMT) so important in many critical developmental processes. The functional regulation of cadherins can occur at many different levels, from transcriptional regulation to the control of the strength of the cadherin-mediated cell-cell interaction. In this review, we will focus on the transcriptional control of cadherin expression, both in development and carcinogenesis, paying particular attention to the regulation of E-cadherin given its proposed role as a suppressor of invasion. We will discuss the main genetic and epigenetic mechanisms involved in down-regulatin...Continue Reading

Citations

Mar 21, 2006·Apoptosis : an International Journal on Programmed Cell Death·L M Bergman, J P Blaydes
Jan 21, 2009·Cancer Metastasis Reviews·Otto SchmalhoferThomas Brabletz
Apr 17, 2010·Cell Biology and Toxicology·Modjtaba Emadi BaygiWolfgang A Schulz
Apr 10, 2008·Clinical & Experimental Metastasis·Laurie G HudsonM Sharon Stack
Jun 15, 2007·Journal of Mammary Gland Biology and Neoplasia·Georgia AgiostratidouRachel B Hazan
May 22, 2010·Journal of Mammary Gland Biology and Neoplasia·Douglas S MicalizziHeide L Ford
Jun 20, 2008·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Yan WuJiawen Li
Dec 16, 2006·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·H Peinado, A Cano
Jun 28, 2011·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Remi-Martin LabergePierre-Yves Desprez
Mar 10, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ludmila PrudkinIgnacio I Wistuba
May 18, 2007·Nature Reviews. Cancer·Héctor PeinadoAmparo Cano
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Jean Paul Thiery, Jonathan P Sleeman
Nov 26, 2008·Oncogene·G Moreno-BuenoA Cano
Sep 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Mirna Perez-MorenoElaine Fuchs
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Allison S HarneyThomas J Meade
Jul 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Denise P MuñozDavid I K Martin
Mar 12, 2008·The Journal of Biological Chemistry·Kelly M Bailey, Jun Liu
Jul 3, 2008·The Journal of Biological Chemistry·Misako HaraguchiMasayuki Ozawa
Oct 4, 2008·The Journal of Biological Chemistry·Sylvie ThuaultAristidis Moustakas
Sep 21, 2011·Antioxidants & Redox Signaling·Elisa GiannoniPaola Chiarugi
Dec 27, 2005·Carcinogenesis·M Matabuena de YzaguirreJ Fernández-Piqueras
Jun 9, 2009·Carcinogenesis·María Jesús LarribaAlberto Muñoz
May 22, 2010·Carcinogenesis·Haibo XuFrederick C Campbell
Sep 6, 2008·Human Molecular Genetics·Joana Simões-CorreiaGianpaolo Suriano
Jan 10, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Chandra S BathulaSeema Somji
Mar 15, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sergio BerzalAdrián M Ramos
Jul 11, 2012·Development, Growth & Differentiation·Azadeh JalaliAli Nawshad

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.