Transcriptional regulation of cardiac conduction system development: 2004 FASEB cardiac conduction system minimeeting, Washington, DC

The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology
Brett S HarrisR G Gourdie

Abstract

The development of the complex network of specialized cells that form the atrioventricular conduction system (AVCS) during cardiac morphogenesis occurs by progressive recruitment within a multipotent cardiomyogenic lineage. Understanding the molecular control of this developmental process has been the focus of recent research. Transcription factors representative of multiple subfamilies have been identified and include members of zinc-finger subfamilies (GATA4, GATA6 HF-1b), skeletal muscle transcription factors (MyoD), T-box genes (Tbx5), and also homeodomain transcription factors (Msx2 and Nkx2.5). Mutations in some of these transcription factors cause congenital heart disease and are associated with cardiac abnormalities, including deficits within the AVCS. Mouse models that closely phenocopy known human heart disease provide powerful tools for the study of molecular effectors of AVCS development. Indeed, investigations of the Nkx2.5 haploinsufficient mouse have shown that peripheral Purkinje fibers are significantly underrepresented. This piece of data corroborates our previous work showing in chick, mouse, and humans that Nkx2.5 is elevated in the differentiating AVCS relative to adjacent working ventricular myocardial tis...Continue Reading

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Citations

Mar 10, 2011·Cardiovascular Research·Lucile MiquerolRobert G Kelly
Jan 28, 2005·Journal of Cardiovascular Electrophysiology·Brett S HarrisTerrence X O'Brien
Mar 28, 2007·Heart Failure Clinics·Jau-Nian ChenJohn D Mably
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Nov 28, 2018·Pediatric Cardiology·Shi-Min Yuan

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