Transcriptional regulation of chemokine expression in ovarian cancer

Biomolecules
Bipradeb SinghaIvana Vancurova

Abstract

The increased expression of pro-inflammatory and pro-angiogenic chemokines contributes to ovarian cancer progression through the induction of tumor cell proliferation, survival, angiogenesis, and metastasis. The substantial potential of these chemokines to facilitate the progression and metastasis of ovarian cancer underscores the need for their stringent transcriptional regulation. In this Review, we highlight the key mechanisms that regulate the transcription of pro-inflammatory chemokines in ovarian cancer cells, and that have important roles in controlling ovarian cancer progression. We further discuss the potential mechanisms underlying the increased chemokine expression in drug resistance, along with our perspective for future studies.

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Citations

Apr 2, 2019·Journal of Cellular and Molecular Medicine·Vikas VermaHye Jin You
Mar 8, 2019·International Journal of Molecular Sciences·Himavanth Reddy GatlaMonish Ram Makena
Aug 13, 2015·Oncotarget·Bipradeb SinghaIvana Vancurova
Sep 27, 2018·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Hoda Soleymani AbyanehRaymond Lai
Nov 21, 2020·Expert Review of Gastroenterology & Hepatology·Shifeng FuDengliang Liu
Jul 22, 2018·Cancer Research·Tamer B ShabanehMary Jo Turk
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shih-Yi HsuFeng Cheng

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Methods Mentioned

BETA
Acetylation
nuclear translocation
histone acetylation
electrophoretic
immunoprecipitations

Software Mentioned

Alggen

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