Transcriptional regulation of dendritic cell diversity.

Frontiers in Immunology
Michaël ChopinGabrielle T Belz

Abstract

Dendritic cells (DCs) are specialized antigen presenting cells that are exquisitely adapted to sense pathogens and induce the development of adaptive immune responses. They form a complex network of phenotypically and functionally distinct subsets. Within this network, individual DC subsets display highly specific roles in local immunosurveillance, migration, and antigen presentation. This division of labor amongst DCs offers great potential to tune the immune response by harnessing subset-specific attributes of DCs in the clinical setting. Until recently, our understanding of DC subsets has been limited and paralleled by poor clinical translation and efficacy. We have now begun to unravel how different DC subsets develop within a complex multilayered system. These findings open up exciting possibilities for targeted manipulation of DC subsets. Furthermore, ground-breaking developments overcoming a major translational obstacle - identification of similar DC populations in mouse and man - now sets the stage for significant advances in the field. Here we explore the determinants that underpin cellular and transcriptional heterogeneity within the DC network, how these influence DC distribution and localization at steady-state, and...Continue Reading

Citations

Feb 16, 2016·Journal of Immunological Methods·Xueheng GuoLi Wu
Feb 12, 2014·Seminars in Cell & Developmental Biology·Michaël Chopin, Stephen L Nutt
Nov 27, 2016·Seminars in Immunopathology·K Sanjana P Devi, Niroshana Anandasabapathy
May 15, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yi ZhangZhaoyang You
Apr 16, 2019·Frontiers in Immunology·Caroline A Jefferies
Dec 24, 2017·Molecular Immunology·Ralph E Vatner, Edith M Janssen
Feb 19, 2019·Cellular Immunology·Pollyana Guimarães de OliveiraMilton Adriano Pelli de Oliveira

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Methods Mentioned

BETA
flow cytometry
dissection

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