Transcriptional regulation of early T-cell development in the thymus

European Journal of Immunology
Wooseok Seo, Ichiro Taniuchi

Abstract

T-cell development occurs in multipotent progenitors arriving in the thymus, which provides a highly specialized microenvironment. Specification and sequential commitment processes to T cells begin in early thymic progenitors upon receiving thymus-specific environmental cues, resulting in the activation of the genetically programmed transcriptional cascade that includes turning on and off numerous transcription factors in a precise manner. Thus, early thymocyte differentiation has been an excellent model system to study cell differentiation processes. This review summarizes recent advances in our knowledge on thymic T-cell development from newly arrived multipotent T-cell progenitors to fully committed T-cell precursors, from the transcriptional regulation perspective.

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Citations

Aug 26, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Renée DaamsRamin Massoumi
Sep 13, 2020·Nature Reviews. Immunology·Hiroyuki Hosokawa, Ellen V Rothenberg
Jan 16, 2021·Trends in Immunology·Chen LiuHongbo Hu
Jan 23, 2021·Proceedings of the National Academy of Sciences of the United States of America·Boyoung ShinEllen V Rothenberg

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