Transcriptional regulation of HLA class-II genes

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Transcriptional regulation of HLA class-II genes

Abstract

References

Chromosomal subunits in active genes have an altered conformation

CpG-rich islands and the function of DNA methylation

Inherited immunodeficiency with a defect in a major histocompatibility complex class II promoter-binding protein differs in the chromatin structure of the HLA-DRA gene.

Anatomy of a new B-cell-specific enhancer.

A FOS protein is present in a complex that binds a negative regulator of MYC

Cloning of the major histocompatibility complex class II promoter binding protein affected in a hereditary defect in class II gene regulation

Congenital immunodeficiencies associated with absence of HLA class II antigens on lymphocytes result from distinct mutations in trans-acting factors

Class II box consensus sequences in the HLA-DR alpha gene: transcriptional function and interaction with nuclear proteins.

New B-lymphocyte-specific enhancer-binding protein.

Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes

The SV40 enhancer contains two distinct levels of organization

Detailed delineation of an interferon-gamma-responsive element important in human HLA-DRA gene expression in a glioblastoma multiform line

Transcription of HLA class II genes in the absence of B-cell-specific octamer-binding factor.

Conserved upstream sequences of human class II major histocompatibility genes enhance expression of class II genes in wild-type but not mutant B-cell lines

Molecular cloning of an enhancer binding protein: isolation by screening of an expression library with a recognition site DNA.

Complete nucleotide sequence of a functional HLA-DP beta gene and the region between the DP beta 1 and DP alpha 1 genes: comparison of the 5' ends of HLA class II genes.

Different roles for cytosine methylation in HLA class II gene expression.

Evidence for chromatin structure as a regulatory determinant in HLA-DR alpha gene expression.

Mapping of the class II region of the human major histocompatibility complex by pulsed-field gel electrophoresis.

Methylation patterns of HLA-DR alpha genes in six mononuclear cell lines.

Organ-specific autoimmunity: a 1986 overview

Megabase-scale mapping of the HLA gene complex by pulsed field gel electrophoresis

Sequence-specific interactions of nuclear factors with conserved sequences of human class II major histocompatibility complex genes

Regulation of a transfected human class II major histocompatibility complex gene in human fibroblasts

Conserved major histocompatibility complex class II boxes--X and Y--are transcriptional control elements and specifically bind nuclear proteins

Transcriptional enhancers in the HLA-DQ subregion.

The HLA-DQ beta gene upstream region contains an immunoglobulin-like octamer motif that binds cell-type specific nuclear factors

Regulation of genes for HLA class II antigens in cell lines from patients with severe combined immunodeficiency

Multiple regulatory regions on the 5' side of the mouse E alpha gene

Molecular analysis of the mouse class II gene, E q alpha

Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X

An enhancer factor defect in a mutant Burkitt lymphoma cell line

Two distinct nuclear factors bind the conserved regulatory sequences of a rabbit major histocompatibility complex class II gene.

Transcriptional activation of HLA-DR alpha by interferon gamma requires a trans-acting protein

Distinct cloned class II MHC DNA binding proteins recognize the X box transcription element

Human class II major histocompatibility complex genes and proteins

B-cell control region at the 5' end of a major histocompatibility complex class II gene: sequences and factors.

B-cell-specific and interferon-gamma-inducible regulation of the HLA-DR alpha gene

Evidence for a trans-acting factor that regulates the transcription of class II major histocompatibility complex genes: genetic and functional analysis

A DNA binding protein regulated by IL-4 and by differentiation in B cells

Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box

A tissue-specific DNase I-hypersensitive site in a class II A alpha gene is under trans-regulatory control

Compartmentalization of MHC class II gene expression in transgenic mice

Affinity purification of sequence-specific DNA binding proteins

A multiplicity of CCAAT box-binding proteins

A tissue-specific transcriptional enhancer is found in the body of the HLA-DR alpha gene

Properties of a CCAAT box-binding protein

Upstream DNA sequences required for tissue-specific expression of the HLA-DR alpha gene

Transgenic mice selectively lacking MHC class II (I-E) antigen expression on B cells: an in vivo approach to investigate Ia gene function

Chromatin structure of the HLA-DR alpha gene in different functional states of major histocompatibility complex class II gene expression.

Citations

Hypomethylation of MHC class II Eb gene is associated with expression

Transcriptional regulation of MHC class II genes

Locus- and allele-specific DNA-protein interactions in the HLA-DQB1 X box

Transcriptional regulation of HLA-DRA gene.

Allelic polymorphism in transcriptional regulatory regions of HLA-DQB genes.

Polymorphisms of the upstream regulatory region of the major histocompatibility complex DRB genes in domestic horses

The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19

An oligonucleotide blocks interferon-gamma signal transduction

Major histocompatibility complex class II-associated invariant chain gene expression is up-regulated by cooperative interactions of Sp1 and NF-Y.

The major histocompatibility complex class II promoter-binding protein RFX (NF-X) is a methylated DNA-binding protein.

Functional effects of a natural polymorphism in the transcriptional regulatory sequence of HLA-DQB1.

Activation of the HLA-DRA gene in primary human T lymphocytes: novel usage of TATA and the X and Y promoter elements.

Complex architecture of major histocompatibility complex class II promoters: reiterated motifs and conserved protein-protein interactions.

Ets-1 activates the DRA promoter in B cells.

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