Transcriptional regulation of IL-2 in health and autoimmunity.

Autoimmunity Reviews
Jose C Crispin, George C Tsokos

Abstract

The regulation of IL-2 production is central to our understanding of the immune system. Key during T cell activation, it also plays an essential role in the regulation of the immune response. This review discusses the function of recently described factors that modulate transcription and chromatin remodeling at the IL2 promoter. Also, it addresses the role of FoxP3 as a transcriptional regulator in conventional T cells and regulatory T cells, and the mechanisms whereby CD28 stabilizes IL2 transcription and translation. Finally, the alterations that prevent T cells from SLE patients from producing normal amounts of IL-2 upon stimulation are described.

References

Jun 3, 2000·Annual Review of Immunology·E M Shevach
Jun 28, 2002·Cell·Fernando MaciánAnjana Rao
Apr 19, 2005·Nature Immunology·Meredith SaffordJonathan D Powell
Oct 15, 2005·The Journal of Clinical Investigation·Christina G KatsiariGeorge C Tsokos
Mar 23, 2006·Annual Review of Immunology·Averil MaPatrick Burkett
Aug 17, 2006·Cytokine & Growth Factor Reviews·Hyoung Pyo KimWarren J Leonard
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Bin LiMark I Greene
Mar 29, 2007·Nucleic Acids Research·Lingfang ShiPeter N Kao
May 16, 2007·Journal of Leukocyte Biology·Whitney S HelmsLishan Su
Jun 15, 2007·The EMBO Journal·Cornelia BrunnerThomas Wirth
Jan 15, 2008·Autoimmunity Reviews·José C Crispín, George C Tsokos

❮ Previous
Next ❯

Citations

May 3, 2012·Molecular Neurobiology·Charlotte AngersteinUwe Klaus Zettl
Sep 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·Hsiao-Wei TsaoI-Cheng Ho
Apr 19, 2012·The Journal of Biological Chemistry·Jeoung-Eun ParkLinda K Myers
Nov 23, 2012·Annals of the Rheumatic Diseases·Lina-Marcela Diaz-GalloUNKNOWN Spanish Scleroderma Group
Aug 2, 2011·Dermatology Research and Practice·Naoki OisoAkira Kawada
Aug 27, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Linda M McAllister-LucasPeter C Lucas
Oct 1, 2011·BMC Immunology·Virginia K Hench, Lishan Su
Oct 5, 2010·Journal of Leukocyte Biology·Tobias WoehrleWolfgang G Junger
Sep 10, 2013·PloS One·Alexandros P GrammatikosGeorge C Tsokos
May 1, 2015·International Journal of Molecular Sciences·Bo Qu, Nan Shen
Dec 14, 2011·Biochemical and Biophysical Research Communications·Hei Jung KimZae Young Ryoo
Aug 31, 2011·Autoimmunity Reviews·Mara Kornete, Ciriaco A Piccirillo
Sep 3, 2011·Trends in Molecular Medicine·Christian M Hedrich, George C Tsokos
Mar 29, 2011·European Journal of Cell Biology·Erwin Hans DuitmanSilvia Bulfone-Paus
Sep 3, 2010·Autoimmunity Reviews·Sheila LangierShmuel Kivity
Jul 20, 2010·Journal of Autoimmunity·Francesca BernuzziGilberto Filaci
Oct 27, 2009·Autoimmunity Reviews·Patrick S C LeungMi-Hua Tao
Dec 19, 2013·Nanotoxicology·Ali KermanizadehVicki Stone
Oct 2, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Emily WaltersBruce F Kimler
Aug 18, 2009·Journal of Autoimmunity·Pietro Invernizzi, M Eric Gershwin
Jul 15, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Bo TangLinda K Myers
Aug 4, 2015·Biological & Pharmaceutical Bulletin·Chiharu MiyajimaHidetoshi Hayashi
Sep 23, 2010·Neurourology and Urodynamics·Yao-Chi ChuangMichael B Chancellor
Sep 12, 2014·Journal of Cellular Biochemistry·Kathleen A BishopJ Wesley Pike
Nov 12, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Li ZhangSyamal K Datta
Sep 27, 2014·Pharmaceutical Biology·Xiao-Li BaoMin-Bo Lan
May 9, 2012·Cellular Immunology·Wang-Dong XuDong-Qing Ye
Apr 25, 2015·PLoS Computational Biology·Katja N RybakovaHans V Westerhoff

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.