Transcriptional regulation of iodothyronine deiodinases during embryonic development

Molecular and Cellular Endocrinology
S Van der GeytenV M Darras

Abstract

A single dose of chicken growth hormone (cGH) or dexamethasone acutely increases circulating T(3) levels in 18-day-old chicken embryos through a reduction of hepatic type III iodothyronine deiodinase (D3). The data in the present study suggest that this decrease in D3 is induced by a direct downregulation of hepatic D3 gene transcription. The lack of effect of cGH or dexamethasone on brain and kidney D3 activity, furthermore suggests that both hormones affect peripheral thyroid hormone metabolism in a tissue specific manner. Dexamethasone administration also results in an increase in brain type II iodothyronine deiodinase (D2) activity and mRNA levels that is also regulated at a transcriptional level. In contrast, however, cGH has no effect on brain D2 activity, thereby suggesting that either GH cannot pass through the blood-brain barrier in chicken or that cGH and dexamethasone regulate thyroid hormone deiodination by different mechanisms. In addition, the very short half-life of D2 and D3 (t(1/2)<1 h) in comparison with the longer half life of type I iodothyronine deiodinase (D1, t(1/2)>8 h), allows for D2 and D3 to play a more prominent role in the acute regulation of peripheral thyroid hormone metabolism than D1.

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Citations

Apr 6, 2004·Molecular and Cellular Endocrinology·Carla H J VerhoelstSerge Van der Geyten
Sep 1, 2005·Thyroid : Official Journal of the American Thyroid Association·Balázs Gereben, Domenico Salvatore
Sep 1, 2005·Thyroid : Official Journal of the American Thyroid Association·Arturo Hernandez
Sep 1, 2005·Thyroid : Official Journal of the American Thyroid Association·Stephen A Huang
Feb 21, 2006·Thyroid : Official Journal of the American Thyroid Association·Veerle M DarrasSerge Van der Geyten
Jul 25, 2012·The Journal of Endocrinology·Veerle M Darras, Stijn L J Van Herck
Feb 14, 2016·General and Comparative Endocrinology·Yugo WatanabeBert De Groef
Dec 23, 2004·General and Comparative Endocrinology·G E ReynsS Van der Geyten
Aug 2, 2005·Domestic Animal Endocrinology·S M E GeelissenV M Darras
May 14, 2005·Domestic Animal Endocrinology·E DecuypereV M Darras
May 13, 2008·Bone·Allan J WilliamsGraham R Williams
Oct 30, 2016·General and Comparative Endocrinology·Bin-Yan HsuTon G G Groothuis
Jan 20, 2017·Critical Reviews in Clinical Laboratory Sciences·Drahomira SpringerEliska Potlukova
Oct 12, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Caroline A ShepherdleyVeerle M Darras
Sep 22, 2009·Expert Opinion on Therapeutic Targets·Monica DenticeDomenico Salvatore
Jan 26, 2011·Expert Opinion on Therapeutic Targets·Monica Dentice
Apr 29, 2004·American Journal of Physiology. Endocrinology and Metabolism·Jennifer Slone Wilcoxon, Eva E Redei
Feb 5, 2021·Endocrinology·Annarita NappiDomenico Salvatore
Jun 2, 2005·Domestic Animal Endocrinology·P RudasT Bartha
Dec 13, 2005·General and Comparative Endocrinology·Bert De GroefEduard R Kühn

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