Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina

Nature Reviews. Neuroscience
A SwaroopDouglas Forrest

Abstract

In the developing vertebrate retina, diverse neuronal subtypes originate from multipotent progenitors in a conserved order and are integrated into an intricate laminated architecture. Recent progress in mammalian photoreceptor development has identified a complex relationship between six key transcription-regulatory factors (RORbeta, OTX2, NRL, CRX, NR2E3 and TRbeta2) that determine rod versus M cone or S cone cell fate. We propose a step-wise 'transcriptional dominance' model of photoreceptor cell fate determination, with the S cone representing the default state of a generic photoreceptor precursor. Elucidation of gene-regulatory networks that dictate photoreceptor genesis and homeostasis will have wider implications for understanding the development of nervous system function and for the treatment of neurodegenerative diseases.

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Citations

Sep 1, 2011·Journal of Ocular Biology, Diseases, and Informatics·Rajesh C RaoShiming Chen
Aug 17, 2011·Proceedings of the National Academy of Sciences of the United States of America·José Luis RoyoJosé Luis Gómez-Skarmeta
Oct 19, 2011·Proceedings of the National Academy of Sciences of the United States of America·Guang-Hua Peng, Shiming Chen
Jul 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·Haruka AbeShigetada Nakanishi
Aug 28, 2013·Proceedings of the National Academy of Sciences of the United States of America·Sachihiro C SuzukiRachel O L Wong
Apr 25, 2013·Molecular Biology and Evolution·Fanwei MengJohn H Postlethwait
Jun 11, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Debarshi MustafiKrzysztof Palczewski
Oct 26, 2011·Molecular and Cellular Biology·Zhi WenPaul Ahlquist
Jan 3, 2014·The Journal of Clinical Investigation·Jerome E RogerAnand Swaroop
Dec 27, 2012·BMC Evolutionary Biology·Kelly E O'QuinKaren L Carleton
Feb 26, 2013·BMC Evolutionary Biology·Brandon M InvergoJaume Bertranpetit
May 5, 2012·Molecular Endocrinology·Douglas Forrest, Anand Swaroop
Feb 23, 2012·PloS One·Benjamin J Smith, Patrice D Côté
Mar 10, 2012·PloS One·Shannath L MerbsDonald J Zack
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Sep 21, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lucia ZiccardiPaul A Sieving
Jan 13, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jerome E RogerAnand Swaroop
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Jul 19, 2011·Journal of Thyroid Research·Fabrice ChatonnetFrédéric Flamant
Jun 20, 2012·Documenta Ophthalmologica. Advances in Ophthalmology·Ivan CimaMarko Hawlina

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