PMID: 3301804Aug 1, 1987

Transcriptional regulation of the DAL5 gene in Saccharomyces cerevisiae

Journal of Bacteriology
R RaiT G Cooper


We demonstrate that the DAL5 gene, encoding a necessary component of the allantoate transport system, is constitutively expressed in Saccharomyces cerevisiae. Its relatively high basal level of expression did not increase further upon addition of allantoin pathway intermediates. However, steady-state DAL5 mRNA levels dropped precipitously when a repressive nitrogen source was provided. These control characteristics of DAL5 expression make this gene a good model with which to unravel the mechanism of nitrogen catabolite repression. Its particular advantage relative to other potentially useful genes derives from its lack of control by induction and hence the complicating effects of inducer exclusion.


Dec 1, 1991·Yeast·R G Buckholz, T G Cooper
Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·Daniel C MasisonR B Wickner
Jan 5, 1999·The Journal of Biological Chemistry·R B WicknerH Moriyama
Mar 4, 2000·The Journal of Biological Chemistry·S ScottT G Cooper
Jan 21, 2000·FEMS Microbiology Reviews·E G ter SchureC T Verrips
Aug 15, 2002·Proceedings of the National Academy of Sciences of the United States of America·H K Edskes, R B Wickner
Nov 1, 2001·Proceedings of the National Academy of Sciences of the United States of America·M M PierceR B Wickner
May 18, 2007·Genetics·Frank ShewmakerR B Wickner
Mar 16, 2012·Genetics·Per O Ljungdahl, Bertrand Daignan-Fornier
Jun 2, 2016·Prion·Anton A NizhnikovIrina L Derkatch
Jun 27, 2020·Frontiers in Genetics·Carmen Becerra-RodríguezVirginie Galeote
Nov 19, 2013·Environmental Microbiology·Laura TreuStefano Campanaro
Sep 20, 2017·Proceedings of the National Academy of Sciences of the United States of America·R B WicknerH K Edskes
Jan 24, 2006·PLoS Genetics·Oliver R HomannSusan L Lindquist
Jun 26, 2020·Microbial Pathogenesis·Vanessa Rafaela Milhomem Cruz-LeiteClayton Luiz Borges

Related Concepts

Allantoic acid, monosodium salt
Genes, Fungal
Cis-Trans Test
Oxamic Acid
RNA, Fungal
Poly(A) Tail
Saccharomyces cerevisiae

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