Transcriptional regulation of the human replacement histone gene H3.3B

FEBS Letters
O WittDetlef Doenecke

Abstract

In contrast to the cell-cycle-dependent histone genes, replacement histone genes are transcribed independently of DNA replication and their expression is upregulated during differentiation. We have investigated the transcriptional regulation of the recently characterized human replacement histone gene H3.3B. Using reporter gene assays of promoter-luciferase gene-constructs, we show that promoter activity largely depends on an intact Oct and CRE/TRE element within the proximal 145 bp of the promoter. DNase I footprinting revealed binding of proteins to a 40-bp region covering these two elements. Band shift experiments identified binding proteins as Oct-1 and factors of the CREB/ATF and AP-1 family, respectively. The unexpected transcriptional regulation of this replacement histone gene is discussed.

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Citations

Dec 3, 2004·Molecular Biology of the Cell·K HardyP S Jat
Mar 17, 2005·Bioinformatics·Rajesh ChowdharyVladimir B Bajic
Jun 11, 2010·BMC Systems Biology·Rajesh ChowdharyJun S Liu
Jun 26, 2007·The Journal of Reproduction and Development·Jun TakahashiYukio Kato
Jul 31, 2008·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Zhi-qiang PanBi-feng Gao
Jun 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nami McCartyHarvey Cantor
Nov 16, 2013·Cancer Cell·Benjamin T K Yuen, Paul S Knoepfler
Dec 3, 2014·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Carolina Cavaliéri GomesRicardo Santiago Gomez
Sep 28, 2018·The Journal of Cell Biology·Shweta MendirattaGenevieve Almouzni
Jan 31, 2016·Science China. Life Sciences·Chaoyang XiongGuohong Li
Nov 4, 2017·Biology of Reproduction·Ralph G MeyerMirella L Meyer-Ficca
Mar 18, 2021·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Mudasir RashidSanjay Gupta
Aug 22, 2014·Development·Benjamin T K YuenPaul S Knoepfler
May 8, 2007·The International Journal of Biochemistry & Cell Biology·Eva Fiala-BeerMichael Murray
May 3, 2011·Archives of Biochemistry and Biophysics·Sean M O'NeillMark Kester
May 3, 2011·Archives of Biochemistry and Biophysics·Sean M O'NeillMark Kester

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