Transcriptional regulation of the insulin-like growth factor-I receptor gene in breast cancer

Molecular and Cellular Endocrinology
Rive SarfsteinH Werner

Abstract

The insulin-like growth factor-I receptor (IGF-IR) has an important role in normal mammary gland growth and morphogenesis. In addition, the IGF-IR has been implicated in the initiation and progression of breast cancer. Previous studies have indicated that acquisition of the malignant phenotype in breast cancer is initially IGF-IR dependent. Most breast cancer-derived cell lines and primary tumors express high levels of IGF-IR mRNA and protein, whereas metastatic stages are usually associated with a decrease in IGF-IR levels. Transcription of the IGF-IR gene is controlled by complex interactions involving DNA-binding and non DNA-binding transcription factors. This review highlights selected examples of tumor suppressors, including BRCA1, p53, and WT1, whose mechanism of action involves regulation of IGF-IR gene expression.

References

Dec 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·C K OsborneC L Arteaga
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H WernerD LeRoith
Nov 1, 1989·The Journal of Clinical Investigation·C L ArteagaC K Osborne
Jan 1, 1994·Breast Cancer Research and Treatment·D Yee
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C SellR Baserga
Mar 1, 1996·Nature Genetics·J T HoltR A Jensen
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·H WernerD LeRoith
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·G B SilbersteinC W Daniel
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·T OuchiH Hanafusa
Mar 27, 1998·Breast Cancer Research and Treatment·E SurmaczL Sciacca
Mar 27, 1998·Breast Cancer Research and Treatment·A V LeeD Yee
May 16, 1998·Biochemical and Biophysical Research Communications·G Sourvinos, D A Spandidos
Dec 2, 1999·Experimental Cell Research·R Baserga
May 3, 2000·Journal of Mammary Gland Biology and Neoplasia·E Surmacz
May 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·T OuchiC M Horvath
Jun 17, 2000·Endocrine Reviews·H M KhandwalaK E Friend
Sep 26, 2000·Molecular and Cellular Biology·P AriztiS W Lee
Dec 5, 2000·International Journal of Cancer. Journal International Du Cancer·B SchnarrD Mayer
Jan 13, 2001·Oncogene·Q WangM I Greene
Apr 20, 2001·The Proceedings of the Nutrition Society·R Kaaks, A Lukanova
Dec 26, 2001·Journal of the National Cancer Institute·Y LuM Pollak
Nov 22, 2002·The Journal of Biological Chemistry·Gila IdelmanHaim Werner
Jan 1, 2003·Genes, Chromosomes & Cancer·Haim Werner, Charles T Roberts
Apr 23, 2003·FEBS Letters·Shirley AbramovitchHaim Werner
Jun 10, 2003·International Journal of Cancer. Journal International Du Cancer·Lital Keinan-BokerPetra H M Peeters
Jan 8, 2004·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·S Abramovitch, H Werner

❮ Previous
Next ❯

Citations

Apr 4, 2013·Breast Cancer Research and Treatment·Avital GilamNoam Shomron
Jun 11, 2009·Current Oncology Reports·E Anders Kolb, Richard Gorlick
Jun 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Chi TarnAndrew K Godwin
Jun 6, 2008·Current Opinion in Oncology·Katia Scotlandi, Piero Picci
Dec 24, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Beate C LitzenburgerAdrian V Lee
May 28, 2014·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Haim Werner, Rive Sarfstein
Jul 3, 2015·Molecular and Clinical Oncology·Woo-Young SunJa-Seung Koo
Oct 20, 2010·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Yangxin Li, Yong-Jian Geng
Aug 25, 2009·Gynecologic Oncology·Marie-Claude BeauchampWalter H Gotlieb
Aug 11, 2015·Analytical Cellular Pathology (Amsterdam)·Kallirroi VoudouriDragana Nikitovic
May 16, 2008·Journal of Cell Communication and Signaling·Daniel MauvoisinCatherine Mounier
Dec 30, 2017·Molecular and Clinical Oncology·Heng SunJing Zhong
Mar 6, 2015·World Journal of Gastroenterology : WJG·Ya-Mei WangFeng Ji
Oct 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Meenali M ChitnisValentine M Macaulay
Sep 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eric K RowinskyDale L Ludwig
Sep 13, 2020·Molecular and Cellular Endocrinology·Haim Werner, Zvi Laron
Jul 6, 2021·Frontiers in Endocrinology·Laris AchlaugIlan Bruchim
Mar 30, 2010·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·S Kalla SinghD De León

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.