Transcriptional regulation of tracheo-bronchial mucin (TBM) gene by ethanol

Gene
M Verma, E A Davidson

Abstract

The epithelia of the respiratory tract are protected by a mucin glycoprotein. The expression of mucin changes when epithelia come in contact with toxic agents such as ethanol. Previously, we have identified and characterized the expression of a tracheo-bronchial mucin (TBM) gene. In the present study, we observed that ethanol regulates TBM expression at the transcription level. Ethanol enhanced the expression of TBM mRNA in a dose- and time-dependent manner in HBE1 cells. At 100 mM concentration (a concentration reported to be present in alcoholics), ethanol induced an eight-fold increase in TBM transcription as determined by reporter gene expression analysis.

References

Apr 14, 1992·Biochimica Et Biophysica Acta·M F MilesV DeGuzman
Dec 1, 1994·Glycobiology·M VermaE A Davidson
Dec 1, 1994·American Journal of Respiratory Cell and Molecular Biology·J A Voynow, M C Rose
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M Verma, E A Davidson

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Citations

Jul 11, 1998·Alcoholism, Clinical and Experimental Research·H E GrenettF M Booyse
Jul 11, 2000·Alcoholism, Clinical and Experimental Research·E M TabengwaF M Booyse
Mar 10, 2001·Alcoholism, Clinical and Experimental Research·E M TabengwaF M Booyse
Sep 4, 2007·Alcohol·Joseph H Sisson

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