Transcriptional regulatory circuits controlling muscle fiber type switching

Science China. Life Sciences
Jing LiuZhenji Gan

Abstract

Skeletal muscle fitness plays vital roles in human health and disease and is determined by developmental as well as physiological inputs. These inputs control and coordinate muscle fiber programs, including capacity for fuel burning, mitochondrial ATP production, and contraction. Recent studies have demonstrated crucial roles for nuclear receptors and their co-activators, and microRNAs (miRNAs) in the regulation of skeletal muscle energy metabolism and fiber type determination. In this review, we present recent progress in the study of nuclear receptor signaling and miRNA networks in muscle fiber type switching. We also discuss the therapeutic potential of nuclear receptors and miRNAs in disease states that are associated with loss of muscle fitness.

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Citations

Apr 12, 2015·Science China. Life Sciences·Xiang Gao
Apr 16, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jisong AhnYoung Jin Jang
Oct 16, 2016·The Journal of Biological Chemistry·Xijun LiangZhenji Gan
Apr 8, 2021·American Journal of Physiology. Cell Physiology·Ying PengXiao Li
Sep 30, 2021·Journal of Agricultural and Food Chemistry·Peiyuan LiGuangning Kou
Feb 20, 2020·Seminars in Cell & Developmental Biology·Elena NikonovaMaria L Spletter

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