Transcriptional reprogramming in cellular quiescence

RNA Biology
Benjamin RocheRobert Martienssen

Abstract

Most cells in nature are not actively dividing, yet are able to return to the cell cycle given the appropriate environmental signals. There is now ample evidence that quiescent G0 cells are not shut-down but still metabolically and transcriptionally active. Quiescent cells must maintain a basal transcriptional capacity to maintain transcripts and proteins necessary for survival. This implies a tight control over RNA polymerases: RNA pol II for mRNA transcription during G0, but especially RNA pol I and RNA pol III to maintain an appropriate level of structural RNAs, raising the possibility that specific transcriptional control mechanisms evolved in quiescent cells. In accordance with this, we recently discovered that RNA interference is necessary to control RNA polymerase I transcription during G0. While this mini-review focuses on yeast model organisms (Saccharomyces cerevisiae and Schizosaccharomyces pombe), parallels are drawn to other eukaryotes and mammalian systems, in particular stem cells.

References

Jul 1, 1995·Applied and Environmental Microbiology·J D Oliver, R Bockian
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·M NakanishiJ R Smith
Apr 1, 1993·The Journal of Pathology·B AnsariP A Hall
Mar 7, 1996·Nature·K H CampbellI Wilmut
Aug 2, 1996·The Journal of Biological Chemistry·N RivardJ Pouysségur
Aug 1, 1996·Molecular Biology of the Cell·F D IveyK A Borkovich
Feb 27, 1997·Nature·I WilmutK H Campbell
May 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·J Klein, I Grummt
Mar 21, 2002·Nature Reviews. Cancer·M Malumbres, M Barbacid
Aug 24, 2002·Science·Thomas A VolpeRobert A Martienssen
Sep 18, 2002·The EMBO Journal·Joseph J SandmeierJeffrey S Smith
Jan 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ira M HallShiv I S Grewal
Mar 13, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Stephen Cooper
Mar 18, 2003·Molecular and Cellular Biology·Nicholas C LeaN Shaun B Thomas
May 8, 2003·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Tom VolpeRobin C Allshire
Oct 17, 2003·Current Biology : CB·Barbara G MelloneRobin C Allshire
Jun 10, 2004·Microbiology and Molecular Biology Reviews : MMBR·Joseph V GrayMargaret Werner-Washburne
Jun 28, 2005·Trends in Immunology·Toshio SudaAtsushi Hirao
Jul 23, 2005·The EMBO Journal·Harald Mikkers, Jonas Frisén
Oct 6, 2005·Journal of Cellular Physiology·Jörn BullwinkelThomas Scholzen
Dec 24, 2005·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Satoru Mochida, Mitsuhiro Yanagida
Jan 18, 2006·Nature Reviews. Microbiology·Steven E Finkel
Mar 3, 2006·PLoS Biology·Hilary A CollerJames M Roberts
Jul 5, 2006·The Journal of Cell Biology·Chris AllenMargaret Werner-Washburne
Aug 18, 2006·Molecular Biology of the Cell·Isabelle SagotBertrand Daignan-Fornier
Jan 11, 2007·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Kazuko MatsubaraMasami Horikoshi
Feb 10, 2007·Cell·Tomoyasu SugiyamaShiv I S Grewal
Feb 14, 2007·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Toshiki A KohdaMasayuki Yamamoto
May 31, 2007·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Mizuki ShimanukiMitsuhiro Yanagida
Oct 25, 2007·Nature Reviews. Cancer·Julio A Aguirre-Ghiso
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lina A ThorénSten-Eirik W Jacobsen
Mar 28, 2008·Nature Cell Biology·Guang YaoLingchong You
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·H R Ueda
May 28, 2008·The Journal of Cell Biology·Damien LaporteIsabelle Sagot
Sep 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Georgia SchäferHugh-G Patterton
Oct 14, 2008·Epigenetics : Official Journal of the DNA Methylation Society·Justin BrumbaughJoshua J Coon

❮ Previous
Next ❯

Citations

Apr 7, 2018·ELife·Richard Scott Marshall, Richard David Vierstra
Aug 29, 2017·Cell Cycle·Benjamin RocheRob Martienssen
May 6, 2019·Current Genetics·Sarah G Swygert, Toshio Tsukiyama
May 6, 2019·International Journal of Molecular Sciences·Karamat MohammadVladimir I Titorenko
Jun 20, 2019·RNA Biology·Sonali BhattacharjeeRobert A Martienssen
Jan 14, 2020·The EMBO Journal·Eleazar RodriguezMorten Petersen
Jan 4, 2019·Journal of Cell Science·Isabelle Sagot, Damien Laporte
Jan 17, 2019·Current Genetics·Isabelle Sagot, Damien Laporte
Jun 10, 2020·Antioxidants·Yuxiang ZhuRebecca E Oberley-Deegan
Jul 30, 2019·Frontiers in Oncology·Maria Laura De AngelisAnn Zeuner
Jul 8, 2020·International Journal of Molecular Sciences·Karamat MohammadVladimir I Titorenko
Dec 15, 2018·International Journal of Cancer. Journal International Du Cancer·Ling BiQihan Dong
Dec 23, 2020·Yeast·Siyu Sun, David Gresham
Jun 9, 2021·Molecular Systems Biology·Samantha A O'ConnorChristopher L Plaisier
Jul 31, 2021·Nature Microbiology·Michael Blatzer, Jean-Paul Latgé
Aug 8, 2021·Current Genetics·Arjuna Rao VallabhaneniHeather Conrad-Webb
Aug 27, 2021·Journal of Fungi·Hannah M Edwards, Johanna Rhodes
Feb 18, 2020·Journal of Molecular Biology·Stéphane Coulon, Mélina Vaurs

❮ Previous
Next ❯

Methods Mentioned

BETA
deamination
acetylation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.