Transcriptionally active regions are the preferred targets for chromosomal HPV integration in cervical carcinogenesis

PloS One
Irene Kraus ChristiansenEivind Hovig

Abstract

Integration of human papillomavirus (HPV) into the host genome is regarded as a determining event in cervical carcinogenesis. However, the exact mechanism for integration, and the role of integration in stimulating cancer progression, is not fully characterized. Although integration sites are reported to appear randomly distributed over all chromosomes, fragile sites, translocation break points and transcriptionally active regions have all been suggested as being preferred sites for integration. In addition, more recent studies have reported integration events occurring within or surrounding essential cancer-related genes, raising the question whether these may reflect key events in the molecular genesis of HPV induced carcinomas. In a search for possible common denominators of the integration sites, we utilized the chromosomal coordinates of 121 viral-cellular fusion transcripts, and examined for statistical overrepresentation of integration sites with various features of ENCODE chromatin information data, using the Genomic HyperBrowser. We find that integration sites coincide with DNA that is transcriptionally active in mucosal epithelium, as judged by the relationship of integration sites to DNase hypersensitivity and H3K4me...Continue Reading

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Citations

Jun 14, 2016·International Journal of Genomics·Juliana GonçalvesAldina Brás
Sep 29, 2018·Genes, Chromosomes & Cancer·Emmanuelle JeannotXavier Sastre-Garau
Nov 10, 2016·PloS One·Poulami DasRita Mulherkar
Apr 7, 2017·PLoS Pathogens·Alison A McBride, Alix Warburton
Jun 28, 2016·International Journal of Cancer. Journal International Du Cancer·Clara BodelonNicolas Wentzensen
May 28, 2019·Frontiers in Oncology·Tarik Gheit
Mar 7, 2021·Viruses·Ashley N Della FeraAlison A McBride
Aug 31, 2021·Seminars in Radiation Oncology·Pippa F CosperRandall J Kimple

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Methods Mentioned

BETA
biopsy
acetylation
chip-seq

Software Mentioned

Ensembl
APOT
Genomic HyperBrowser
Refseq

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