Transcriptome analysis and kidney research: toward systems biology

Kidney International
Mingyu LiangJennifer L Pietrusz

Abstract

An enormous amount of data has been generated in kidney research using transcriptome analysis techniques. In this review article, we first describe briefly the principles and major characteristics of several of these techniques. We then summarize the progress in kidney research that has been made by using transcriptome analysis, emphasizing the experience gained and the lessons learned. Several technical issues regarding DNA microarray are highlighted because of the rapidly increased use of this technology. It appears clear from this brief survey that transcriptome analysis is an effective and important tool for question-driven exploratory science. To further enhance the power of this and other high throughput, as well as conventional approaches, in future studies of the kidney, we propose a multidimensional systems biology paradigm that integrates investigation at multiple levels of biologic regulation toward the goal of achieving a global understanding of physiology and pathophysiology.

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Citations

Oct 6, 2007·Biological & Pharmaceutical Bulletin·Junji TakayamaYasuo Matsumura
Apr 18, 2008·Journal of the American Society of Nephrology : JASN·Takefumi MoriAllen W Cowley
Sep 10, 2013·Seminars in Nephrology·Mingyu LiangYong Liu
Aug 29, 2006·Biochemical and Biophysical Research Communications·Dumitru A IacobasGabriel G Haddad
Feb 14, 2006·Trends in Cardiovascular Medicine·Yoram Yagil, Chana Yagil
Mar 5, 2008·Hypertension·Zhongmin TianMingyu Liang
Feb 17, 2005·Physiological Genomics·Kristen E KnollMingyu Liang
Jan 13, 2006·Journal of the American Society of Nephrology : JASN·Katalin Susztak, Erwin P Böttinger
May 19, 2006·Journal of the American Society of Nephrology : JASN·Prasad Devarajan

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