Transcriptome analysis in tardigrade species reveals specific molecular pathways for stress adaptations.

Bioinformatics and Biology Insights
Frank FörsterThomas Dandekar

Abstract

Tardigrades have unique stress-adaptations that allow them to survive extremes of cold, heat, radiation and vacuum. To study this, encoded protein clusters and pathways from an ongoing transcriptome study on the tardigrade Milnesium tardigradum were analyzed using bioinformatics tools and compared to expressed sequence tags (ESTs) from Hypsibius dujardini, revealing major pathways involved in resistance against extreme environmental conditions. ESTs are available on the Tardigrade Workbench along with software and databank updates. Our analysis reveals that RNA stability motifs for M. tardigradum are different from typical motifs known from higher animals. M. tardigradum and H. dujardini protein clusters and conserved domains imply metabolic storage pathways for glycogen, glycolipids and specific secondary metabolism as well as stress response pathways (including heat shock proteins, bmh2, and specific repair pathways). Redox-, DNA-, stress- and protein protection pathways complement specific repair capabilities to achieve the strong robustness of M. tardigradum. These pathways are partly conserved in other animals and their manipulation could boost stress adaptation even in human cells. However, the unique combination of resis...Continue Reading

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Citations

Apr 2, 2016·Proceedings of the National Academy of Sciences of the United States of America·Georgios KoutsovoulosMark Blaxter
Dec 18, 2013·The Journal of Heredity·UNKNOWN GIGA Community of ScientistsXin Zhou
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Dec 15, 2012·The Journal of Experimental Biology·Kenneth Agerlin HalbergNadja Møbjerg

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Datasets Mentioned

BETA
CO508035.1
CZ258529.1
GE637688.1
CO741640.1
CO741254.1
CK326237.1
CO741993.1
GE637487.1
GR865643.1
EZ758936.1

Methods Mentioned

BETA
protein folding
environmental stress
PCR
CLANS
nucleotide exchange

Software Mentioned

tardigrade analyzer
Scan
TBLASTX
Interpro
UTR
Inparanoid
Tardigrade Workbench
BLAST
Prosite Motifs
CLANS

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