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Transcriptome analysis of an antibiotic downregulator mutant and synergistic Actinorhodin stimulation via disruption of a precursor flux regulator in Streptomyces coelicolor

Applied and Environmental Microbiology

Jan 11, 2011

Seon-Hye KimEung-Soo Kim

Abstract

Through microarray analysis of an antibiotic-downregulator-deleted Streptomyces coelicolor ΔwblA ΔSCO1712 mutant, 28 wblA- and SCO1712-dependent genes were identified and characterized. Among 14 wblA- and SCO1712-independent genes, a carbon flux regulating 6-phosphofructokinase SCO5426 ...read more

Mentioned in this Paper

Gene Expression Regulation, Bacterial
Biochemical Pathway
Microarray Analysis
Metabolic Networks and Pathways
Streptomyces coelicolor
Vitreous Carbon
Streptomyces coelicolor A3(2)
Gene Deletion
Anthraquinones
Genes, vif
Paper Details
References
  • References17
  • Citations12
12
  • References17
  • Citations12
12

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Transcriptome analysis of an antibiotic downregulator mutant and synergistic Actinorhodin stimulation via disruption of a precursor flux regulator in Streptomyces coelicolor

Applied and Environmental Microbiology

Jan 11, 2011

Seon-Hye KimEung-Soo Kim

PMID: 21216912

DOI: 10.1128/aem.02346-10

Abstract

Through microarray analysis of an antibiotic-downregulator-deleted Streptomyces coelicolor ΔwblA ΔSCO1712 mutant, 28 wblA- and SCO1712-dependent genes were identified and characterized. Among 14 wblA- and SCO1712-independent genes, a carbon flux regulating 6-phosphofructokinase SCO5426 ...read more

Mentioned in this Paper

Gene Expression Regulation, Bacterial
Biochemical Pathway
Microarray Analysis
Metabolic Networks and Pathways
Streptomyces coelicolor
Vitreous Carbon
Streptomyces coelicolor A3(2)
Gene Deletion
Anthraquinones
Genes, vif

Trending Feeds

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Related Papers

The Journal of Biological Chemistry

Antibiotic overproduction in Streptomyces coelicolor A3 2 mediated by phosphofructokinase deletion

The Journal of Biological ChemistryJuly 9, 2008
Irina BorodinaJens Nielsen
Paper Details
References
  • References17
  • Citations12
12
  • References17
  • Citations12
12
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