Transcriptome analysis of HPV-induced warts and healthy skin in humans

BMC Medical Genomics
Laith N Al-EitanHadeel S Al-Kofahi

Abstract

The human papillomaviruses (HPV) are a group of viruses that, depending on the strain, can cause cancer or the formation of benign growths known as warts. Scarce information exists with regard to the genetic nature of non-genital cutaneous warts induced by the human papillomavirus (HPV). The main purpose of this study is to investigate the differences between the gene expression profiles of common warts and healthy skin in HPV-positive individuals by RNA sequencing on the Illumina HiSeq 2500. After obtaining shave biopsies of common warts and healthy skin from twelve Arab males, we were able to analyze the transcriptomes of 24 paired cases and controls. Common warts were found to possess a highly significant and unique molecular signature. Many of the most up-regulated (KRT16, EPGN, and ABCG4) and down-regulated genes (C15orf59, CYB561A3, and FCGRT) in warts were the subject of little investigation in the published literature. Moreover, the top 500 differentially expressed genes were found to be associated with immune and autoimmune pathways, such as the neutrophil degranulation, toll-like receptor 7/8 (TLR 7/8) cascade, toll-like receptor 9 (TLR9) cascade, and toll-like receptor 10 (TLR10) pathways, among others. Our findings ...Continue Reading

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Citations

Jan 12, 2021·Saudi Journal of Biological Sciences·Mansour A AlghamdiFiras A Al-Qarqaz
Apr 29, 2021·European Journal of Histochemistry : EJH·Li NiuWei Zeng

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Methods Mentioned

BETA
biopsy
RNA-seq
genotyping
biopsies

Software Mentioned

Illumina
VirusTAP
HiSeq Control Software ( HCS )
megablast
ComplexHeatmap
edgeR
ClustVis
ReactomePA
Real Time Analysis ( RTA )
Signaling Network Open Resource

Related Concepts

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