Transcriptome analysis of miRNA-lncRNA-mRNA interactions in the malignant transformation process of gastric cancer initiation

Cancer Gene Therapy
Y MaoH Wang

Abstract

Gastric cancer is a common heterogeneous malignancy that is pathologically characterized by the development of chronic atrophic gastritis and dysplasia of the epithelium. The pathogenic mechanisms at the molecular level are completely unclear. In the present study, we first address the expression network and miRNA-lncRNA-mRNA interaction in the malignant transformation process from normal mucosa and atrophic gastritis to a tumor. First, the long non-coding RNA (lncRNA), micro RNA (miRNA) and messenger RNA (mRNA) expression profiles of normal gastric mucosa, atrophic gastritis, gastric cancer and the peri-tumor tissues were analyzed using microarrays. Then, bioinformatic analyses were used to predict the gene targets and analyse their potential roles in tumorigenesis and progression of gastric cancer. Finally, an intersection analysis of microarray data showed that 10 miRNAs and 11 lncRNAs were detected in the malignant transformation process from normal mucosa tissues and atrophic gastritis to tumorigenesis, and many miRNAs and lncRNAs were novel and had important roles. Meanwhile, the significant pathways and biological functions regulated by the deregulated 21 non-coding genes were enriched. In conclusion, our work provides a...Continue Reading

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Citations

Jun 13, 2019·Journal of Cellular Physiology·Chengmin ShiYujian Zeng
May 19, 2019·CNS Neuroscience & Therapeutics·Yuan-Feng GaoZhao-Qian Liu
Jan 26, 2020·Pathogens and Disease·Narges DastmalchiReza Safaralizadeh
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Aug 9, 2019·Journal of Experimental & Clinical Cancer Research : CR·Chen QiJiang Jianshuai
Feb 8, 2020·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Lei GaoQihong Zhao
Feb 9, 2021·Digestive Diseases and Sciences·Linsong MuZhongchuan Lv
Oct 30, 2020·OncoTargets and Therapy·Ming-Dian LuYong-Xiang Li
Jun 11, 2021·Acta Biochimica Et Biophysica Sinica·Fang WeiYan Li
Aug 17, 2021·Cancer Management and Research·Chuanming TongXiongsheng Xiao

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Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

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