Transcriptome analysis predicts mode of action of benzimidazole molecules against Staphylococcus aureus UAMS-1

Drug Development Research
Deepika ChauhanSubhabrata Sen

Abstract

Antimicrobial drug resistance is one of the most critical problems that plagued the human race in modern times. Discovery of novel antibiotics is important to counter this threat. Accordingly, herein we have reported the discovery of substituted benzimidazole class of molecules with antimicrobial property (specifically against Staphylococcus aureus). They were initially identified through a random screening and a novel catalytic synthetic strategy was utilized to access them. in vitro screening and phenotypic profiling revealed the antimicrobial nature. De novo transcriptome and gene analyses predicted the putative targets. This work provides a solid foundation for developing the benzimidazoles as a target specific antimicrobial preclinical candidate.

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Citations

Nov 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Katarzyna ZawadzkaKatarzyna Lisowska
Oct 17, 2019·Drug Development Research·Rungrot CherdtrakulkiatVirapong Prachayasittikul
Dec 19, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Viktor ZvarychSlawomir Milewski

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