Transcriptome changes associated with fat deposition in the longissimus thoracis of Korean cattle following castration.

Journal of Animal Physiology and Animal Nutrition
Sang Weon NaMyunggi Baik

Abstract

The castration of bulls increases the intramuscular fat (IMF) content in skeletal muscle. However, the biological processes of IMF accumulation in skeletal muscle after castration are not completely understood at the molecular level. This study examined the global transcriptomic changes in the longissimus thoracis muscle (LT) of bulls following castration using RNA sequencing (RNA-Seq) and identified new genes or pathways associated with beef quality. Ten bulls and 10 steers castrated at 6 months of age were slaughtered at 26 and 32 months of age respectively. For transcriptome analysis, six LT samples from three bulls and three steers were selected based on age, carcass weight, carcass quantity and beef quality grades. Using RNA-Seq, transcriptomic profiles of the LT were compared between bulls and steers. In all, 640 of the 18,027 genes identified through RNA-Seq were differentially expressed genes (DEGs) between bulls and steers. Pathway analysis of these 640 DEGs showed significant (p < .05) changes in seven Kyoto Encyclopedia of Genes and Genomes pathways, and the most significant terms were complement and coagulation cascade pathways. The transcriptomic expression patterns of 10 genes in the complement and coagulation cas...Continue Reading

References

Nov 24, 2001·Blood·F SamadD J Loskutoff
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A MartíJ A Martínez
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Erin E Kershaw, Jeffrey S Flier
Sep 10, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·T Skurk, H Hauner
Nov 30, 2006·Pharmacological Reviews·Liliane MichalikWalter Wahli
Dec 23, 2006·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·K A L DarvallD J Adam
Mar 6, 2007·Trends in Immunology·Maciej M MarkiewskiJohn D Lambris
Dec 7, 2007·Biochemical and Biophysical Research Communications·Masaaki TaniguchiStephen S Moore
Sep 30, 2008·Journal of Animal Science·Y H WangS A Lehnert
Nov 19, 2008·Nature Reviews. Genetics·Zhong WangMichael Snyder
Oct 31, 2009·Advances in Medical Sciences·M GnacińskaK Sworczak
Dec 17, 2009·The Biochemical Journal·Meilian Liu, Feng Liu
May 4, 2010·Trends in Immunology·Andreas Schäffler, Jürgen Schölmerich
Jun 19, 2012·Trends in Endocrinology and Metabolism : TEM·Walter Wahli, Liliane Michalik
May 9, 2013·Nature Medicine·Maryam AhmadianRonald M Evans
May 21, 2013·Seminars in Immunology·Julia PhielerTriantafyllos Chavakis
Sep 18, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julia PhielerTriantafyllos Chavakis
Jan 6, 2015·Asian-Australasian Journal of Animal Sciences·Myunggi BaikHyeok Joong Kang
Jan 28, 2015·Hämostaseologie·W Ruf, F Samad
May 5, 2017·Cardiovascular Research·Gemma VilahurLina Badimon
Jul 25, 2017·The Journal of Clinical Investigation·Anna K KopecMatthew J Flick
Mar 6, 2018·Asian-Australasian Journal of Animal Sciences·Dilla Mareistia FassahMyunggi Baik
Jun 9, 2018·Asian-Australasian Journal of Animal Sciences·Seung Ju ParkMyunggi Baik

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.