Transcriptome hallmarks in Helicobacter pylori infection influence gastric cancer and MALT lymphoma.

Epigenomics
Jian ZhangDongjie Yang

Abstract

Aim: Altered long noncoding RNA (lncRNA) and mRNA is vital in the progression from Helicobacter pylori (H. pylori, HP) infection to gastric cancer (GC) and mucosa-associated lymphoid tissue (MALT) lymphoma. Materials & methods: Five independent Gene Expression Omnibus datasets (GSE5081, GSE84433, GSE15459, GSE66229 and GSE25638) were included in our study. Results: Differentially expressed lncRNAs and mRNAs in both H. pylori-positive gastritis and GC tissues were identified. Using two GC cohorts, the H. pylori-related mRNA DYNC1I1 and MMP7 were independent predictors of overall survival. Moreover, the expressions of lncRNA GHRLOS and 44 mRNAs were significantly changed in gastric MALT lymphoma patients. Conclusion: The lncRNA/mRNA response to H. pylori infection in gastritis and GC influence the outcome of GC and progression of MALT lymphoma.

References

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Datasets Mentioned

BETA
GSE66229
GSE25638
GPL6947
GSE5081

Software Mentioned

NetworkAnalyst
ArrayTools
Cytoscape
BRB
GENCODE
Database for Annotation , Visualization , and Integrated Disco...
R

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