Transcriptome profiling reveals novel BMI- and sex-specific gene expression signatures for human cardiac hypertrophy

Physiological Genomics
Mackenzie S NewmanHan-Gang Yu

Abstract

How obesity or sex may affect the gene expression profiles of human cardiac hypertrophy is unknown. We hypothesized that body-mass index (BMI) and sex can affect gene expression profiles of cardiac hypertrophy. Human heart tissues were grouped according to sex (male, female), BMI (lean<25 kg/m2, obese>30 kg/m2), or left ventricular hypertrophy (LVH) and non-LVH nonfailed controls (NF). We identified 24 differentially expressed (DE) genes comparing female with male samples. In obese subgroup, there were 236 DE genes comparing LVH with NF; in lean subgroup, there were seven DE genes comparing LVH with NF. In female subgroup, we identified 1,320 significant genes comparing LVH with NF; in male subgroup, there were 1,383 significant genes comparing LVH with NF. There were seven significant genes comparing obese LVH with lean NF; comparing male obese LVH with male lean NF samples we found 106 significant genes; comparing female obese LVH with male lean NF, we found no significant genes. Using absolute value of log2 fold-change > 2 or extremely small P value (10-20) as a criterion, we identified nine significant genes (HBA1, HBB, HIST1H2AC, GSTT1, MYL7, NPPA, NPPB, PDK4, PLA2G2A) in LVH, also found in published data set for ischemic ...Continue Reading

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Citations

Oct 19, 2019·Aging Cell·Fabiola Marín-AguilarMario D Cordero
Jun 3, 2020·The Journal of Clinical Investigation·Gaelle AugusteAli J Marian
Oct 9, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takeshi TakamiKazuomi Kario

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Methods Mentioned

BETA
biopsy
RNA-Seq
PCR
X-ray
biopsies

Software Mentioned

Enrichr
FastQ
GeneMANIA
RStudio
ARSyNseq
GeneChip
DeSeq
noiseqbio
Spliced Transcripts Alignment to a Reference ( STAR )
Ensembl

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