Transcriptome responses to heat stress in hypothalamus of a meat-type chicken

Journal of Animal Science and Biotechnology
Hongyan SunLujiang Qu

Abstract

Heat stress has resulted in great losses in poultry production. To address this issue, we systematically analyzed chicken hypothalamus transcriptome responses to thermal stress using a 44 k chicken Agilent microarray. Hypothalamus samples were collected from a control group reared at 25°C, a heat-stress group treated at 34°C for 24 h, and a temperature-recovery group reared at 25°C for 24 h following a heat-stress treatment. We compared the expression profiles between each pair of the three groups using microarray data. A total of 1,967 probe sets were found to be differentially expressed in the three comparisons with P < 0.05 and a fold change (FC) higher than 1.5, and the genes were mainly involved in self-regulation and compensation required to maintain homeostasis. Consistent expression results were found for 11 selected genes by quantitative real-time PCR. Thirty-eight interesting differential expression genes were found from GO term annotation and those genes were related to meat quality, growth, and crucial enzymes. Using these genes for genetic network analysis, we obtained three genetic networks. Moreover, the transcripts of heat-shock protein, including Hsp 40 and Hsp 90, were significantly altered in response to ther...Continue Reading

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Citations

Feb 27, 2019·Stress : the International Journal on the Biology of Stress·Hossein HassanpourWaranyoo Kaewduangta
Nov 9, 2017·Stress : the International Journal on the Biology of Stress·Shahab BahadoranHossein Hassanpour
Jul 22, 2018·Scientific Reports·Yoel Rodriguez-ValeraYuliaxis Ramayo-Caldas
Nov 21, 2017·Animal Science Journal = Nihon Chikusan Gakkaihō·Shozo TomonagaRyosuke Makino
Jan 2, 2021·Animals : an Open Access Journal From MDPI·Francesco PeriniEmiliano Lasagna
Jan 23, 2021·Animals : an Open Access Journal From MDPI·Dane W FausnachtRobert P Rhoads

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Datasets Mentioned

BETA
16562670

Methods Mentioned

BETA
Feature Extraction
PCR
electrophoresis
PCA
protein folding

Software Mentioned

DAVID
Gene Spring
SAS
R
Primer Express
Feature Extraction
IPA
Ingenuity Pathway Analysis ( IPA )

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