Transcriptome-scale similarities between mouse and human skeletal muscles with normal and myopathic phenotypes

BMC Musculoskeletal Disorders
Alvin T KhoLouis M Kunkel

Abstract

Mouse and human skeletal muscle transcriptome profiles vary by muscle type, raising the question of which mouse muscle groups have the greatest molecular similarities to human skeletal muscle. Orthologous (whole, sub-) transcriptome profiles were compared among four mouse-human transcriptome datasets: (M) six muscle groups obtained from three mouse strains (wildtype, mdx, mdx5cv); (H1) biopsied human quadriceps from controls and Duchenne muscular dystrophy patients; (H2) four different control human muscle types obtained at autopsy; and (H3) 12 different control human tissues (ten non-muscle). Of the six mouse muscles examined, mouse soleus bore the greatest molecular similarities to human skeletal muscles, independent of the latters' anatomic location/muscle type, disease state, age and sampling method (autopsy versus biopsy). Significant similarity to any one mouse muscle group was not observed for non-muscle human tissues (dataset H3), indicating this finding to be muscle specific. This observation may be partly explained by the higher type I fiber content of soleus relative to the other mouse muscles sampled.

References

Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·V M ChapmanC T Caskey
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G BulfieldK J Moore
Aug 1, 1993·Journal of Muscle Research and Cell Motility·P MoensG Maréchal
Mar 15, 1994·Biochemical and Biophysical Research Communications·F SamsonJ R Gilbert
Sep 1, 1993·The American Journal of Physiology·B J PetrofA M Kelly
Nov 24, 1999·Biochimica Et Biophysica Acta·A V TkatchenkoC A Dechesne
Jun 22, 2000·Molecular Cell Biology Research Communications : MCBRC·P T LoughnaC Brownson
Jun 22, 2002·Current Opinion in Genetics & Development·Madeleine Durbeej, Kevin P Campbell
Jul 5, 2002·Genome Research·Jatin MisraGregory Stephanopoulos
Jul 23, 2002·Journal of Applied Physiology·B S TsengF W Booth
Aug 15, 2002·American Journal of Physiology. Cell Physiology·Karl RougerJean J Leger
Nov 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Judith N HaslettLouis M Kunkel
Mar 7, 2003·Human Molecular Genetics·Satoru NoguchiIchizo Nishino
Apr 3, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·John D PorterHenry J Kaminski
Apr 17, 2003·Neurogenetics·Judith N HaslettLouis M Kunkel
Oct 2, 2003·Annals of Neurology·Homa TajsharghiAnders Oldfors
Nov 26, 2003·Investigative Ophthalmology & Visual Science·Daniel KjellgrenFatima Pedrosa-Domellöf
Dec 19, 2003·Nucleic Acids Research·M A HarrisUNKNOWN Gene Ontology Consortium
Jan 22, 2004·European Journal of Applied Physiology·Tohru TakemasaShuko Haga
Jul 30, 2004·BMC Cell Biology·Robert J TalmadgeFrancisco J Naya
Jun 18, 2005·Muscle & Nerve·Peter B KangLouis M Kunkel
Nov 2, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Judith N HaslettLouis M Kunkel
Dec 13, 2006·Nature Biotechnology·Ron Edgar, Tanya Barrett

❮ Previous
Next ❯

Citations

Jun 26, 2012·Brain : a Journal of Neurology·Gisela Nogales-GadeaAntoni L Andreu
Aug 10, 2011·Skeletal Muscle·Matthew S AlexanderLouis M Kunkel
Nov 28, 2012·Experimental Physiology·Robert A JacobsCarsten Lundby
May 18, 2016·Biochimica Et Biophysica Acta·Julie MassartAnna Krook
Feb 10, 2007·Expert Review of Proteomics·Jimmy Lin, Jiang Qian
Jun 17, 2019·Journal of Lipid Research·Vanessa R HaynesMatthew J Watt
Jul 21, 2009·Biochemical Society Transactions·Soumyaroop Bhattacharya, Thomas J Mariani
May 26, 2020·Orphanet Journal of Rare Diseases·Leire Casas-FraileAmets Sáenz
Apr 27, 2021·Molecular Therapy. Methods & Clinical Development·Jennifer BoscoDennis Keefe
May 19, 2021·Skeletal Muscle·Rohan X VermaMarc K Halushka

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
PCA

Software Mentioned

Adobe

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Cell Atlas of the Human Thymus

Examining the genomics, transcriptomics, proteomics, and metabolomics of the human thymus gland at the single cell level will help build a unique profile for each cell type and a three-dimensional map of how cell types work together to form tissues. Discover the latest research on the cell atlas of the human thymus here.